Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTB4R2 | Q9NPC1 | 3/20 | 0.44 |
| ▸ | AGTR1 | P30556 | 10/20 | 0.40 |
| ▸ | AGTR2 | P50052 | 10/20 | 0.40 |
| ▸ | CMKLR1 | Q99788 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | CRHBP | P24387 | 1/20 | 0.36 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.36 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.36 |
| ▸ | OXTR | P30559 | 1/20 | 0.36 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.36 |
| ▸ | BDKRB1 | P46663 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8552360 | 0.85 | LTB4R2 (0.58) | LTB4R2AGTR1 | |
| SCHEMBL8547981 | 0.80 | AGTR1 (0.42) | LTB4R2AGTR1AGTR2CMKLR1 | |
| SCHEMBL8550854 | 0.79 | CMKLR1 (0.42) | LTB4R2AGTR1AGTR2CMKLR1 | |
| SCHEMBL8472095 | 0.75 | FFAR1 (0.41) | LTB4R2AGTR1AGTR2FFAR1AKR1B1 | |
| SCHEMBL9197099 | 0.75 | CMKLR1 (0.42) | LTB4R2AGTR1AGTR2CMKLR1KDM4E | |
| SCHEMBL9194229 | 0.75 | CMKLR1 (0.42) | LTB4R2AGTR1AGTR2CMKLR1KDM4E | |
| SCHEMBL9424056 | 0.75 | AGTR1 (0.67) | AGTR1AGTR2BDKRB1 | |
| SCHEMBL2630 | 0.74 | AGTR1 (0.40) | LTB4R2AGTR1AGTR2FFAR1AKR1B1 | |
| SCHEMBL2918 | 0.74 | AGTR1 (0.40) | LTB4R2AGTR1AGTR2FFAR1AKR1B1 | |
| SCHEMBL8944295 | 0.73 | AGTR1 (0.38) | LTB4R2AGTR1AGTR2CMKLR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0588299-B1 | 1,2,4-Oxadiazolyl- or 1,2,4-thiadiazolyl-biphenyl derivatives as angiotensin II antagonists | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1998-07-01 | — | — | EP | disclosed |
| EP-0829479-A1 | Heterocyclic compounds and their use as angiotensin II antagonists | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1998-03-18 | — | — | EP | disclosed |
| US-5500427-A | ANGIOTENSIN II ANTAGONISTS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1996-03-19 | — | — | US | disclosed |
| EP-0588299-A2 | 1,2,4-Oxadiazolyl- or 1,2,4-thiadiazolyl-biphenyl derivatives as angiotensin II antagonists | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1994-03-23 | — | — | EP | disclosed |