SCHEMBL8552394

SCHEMBL8552394

O=S(=O)(CCOc1ccccc1)C(F)(F)F

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KCNA3 P22001 1/20 0.48
ALDH1A1 P00352 3/20 0.46
HDAC1 Q13547 3/20 0.46
HDAC2 Q92769 3/20 0.46
MGLL Q99685 1/20 0.44
TAAR1 Q96RJ0 1/20 0.44
RECQL P46063 1/20 0.44
TP53 P04637 1/20 0.43
PKM P14618 2/20 0.42
L3MBTL1 Q9Y468 1/20 0.41
HDAC3 O15379 1/20 0.40
HDAC4 P56524 1/20 0.40
HDAC7 Q8WUI4 1/20 0.40
HDAC10 Q969S8 1/20 0.40
HDAC11 Q96DB2 1/20 0.40
HDAC8 Q9BY41 1/20 0.40
HDAC6 Q9UBN7 1/20 0.40
HDAC9 Q9UKV0 1/20 0.40
HDAC5 Q9UQL6 1/20 0.40
DRD2 P14416 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8552660 0.91 KCNA3 (0.52) KCNA3ALDH1A1HDAC1HDAC2MGLL
SCHEMBL11286098 0.78 ALDH1A1 (0.41) KCNA3ALDH1A1HDAC1HDAC2MGLL
SCHEMBL18889128 0.78 KCNA3 (0.48) KCNA3ALDH1A1HDAC1HDAC2TAAR1
SCHEMBL9080146 0.76 KCNA3 (0.52) KCNA3ALDH1A1HDAC1HDAC2MGLL
SCHEMBL16479238 0.75 KCNA3 (0.54) KCNA3ALDH1A1TAAR1RECQLTP53
SCHEMBL4639243 0.75 KCNA3 (0.54) KCNA3ALDH1A1TAAR1RECQLTP53
SCHEMBL5983606 0.75 KCNA3 (0.54) KCNA3ALDH1A1HDAC1HDAC2MGLL
SCHEMBL749431 0.75 KCNA3 (0.54) KCNA3ALDH1A1HDAC1HDAC2MGLL
SCHEMBL5983609 0.75 KCNA3 (0.54) KCNA3ALDH1A1HDAC1HDAC2TAAR1
SCHEMBL30728413 0.74 MEN1 (0.52) ALDH1A1HDAC1HDAC2RECQLL3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0840725-A1 AZETIDINONE DERIVATIVES FOR THE TREATMENT OF ATHEROSCLEROSIS SMITHKLINE BEECHAM PLC (GB) 1998-05-13 EP disclosed
WO-1997002242-A1 AZETIDINONE DERIVATIVES FOR THE TREATMENT OF ATHEROSCLEROSIS SMITHKLINE BEECHAM PLC (GB) 1997-01-23 WO disclosed