Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 1/20 | 0.40 |
| ▸ | SMO | Q99835 | 1/20 | 0.36 |
| ▸ | C1R | P00736 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 3/20 | 0.34 |
| ▸ | RAB9A | P51151 | 3/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.34 |
| ▸ | CASP3 | P42574 | 1/20 | 0.34 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.34 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.34 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 4/20 | 0.34 |
| ▸ | HPGD | P15428 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | TP53 | P04637 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | APAF1 | O14727 | 1/20 | 0.34 |
| ▸ | TDP2 | O95551 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8547106 | 0.88 | SMO (0.41) | ADORA2ASMONPC1RAB9ASMN1; SMN2 | |
| SCHEMBL8552464 | 0.82 | ADORA2A (0.37) | ADORA2ASMONPC1RAB9ASMN1; SMN2 | |
| SCHEMBL8547547 | 0.79 | SMO (0.44) | ADORA2ASMONPC1RAB9ASMN1; SMN2 | |
| SCHEMBL8552241 | 0.78 | ALDH1A1 (0.41) | ADORA2ASMN1; SMN2MAPTHPGDALDH1A1 | |
| SCHEMBL8550781 | 0.78 | ALDH1A1 (0.44) | ADORA2ASMN1; SMN2MAPTHPGDALDH1A1 | |
| SCHEMBL8518061 | 0.76 | PLAU (0.42) | ADORA2ASMOMAPTHPGDALDH1A1 | |
| Hydrochloric Acid SCHEMBL8546931 | 0.75 | PLAU (0.41) | ADORA2ASMOMAPTHPGDALDH1A1 | |
| SCHEMBL8518058 | 0.74 | ADORA2A (0.36) | ADORA2ASMOC1RALDH1A1TSHR | |
| Hydrochloric Acid SCHEMBL8546924 | 0.73 | ADORA2A (0.36) | ADORA2ASMOKDRJAK2JAK1 | |
| SCHEMBL8547763 | 0.72 | ADORA2A (0.38) | ADORA2ASMOSMN1; SMN2MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0825187-A1 | Condensed pyridazinyl guanidines, their production and use | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1998-02-25 | — | — | EP | disclosed |