Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 16/20 | 0.62 |
| ▸ | PTGS1 | P23219 | 6/20 | 0.62 |
| ▸ | NR4A2 | P43354 | 3/20 | 0.45 |
| ▸ | RXRA | P19793 | 2/20 | 0.45 |
| ▸ | RXRB | P28702 | 2/20 | 0.45 |
| ▸ | RXRG | P48443 | 1/20 | 0.45 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7502336 | 0.93 | PTGS2 (0.65) | PTGS2PTGS1NR4A2 | |
| SCHEMBL6022651 | 0.89 | PTGS2 (0.64) | PTGS2PTGS1 | |
| SCHEMBL6025799 | 0.88 | PTGS2 (0.68) | PTGS2PTGS1 | |
| SCHEMBL5732600 | 0.88 | RXRA (0.63) | PTGS2PTGS1NR4A2RXRARXRB | |
| SCHEMBL7500353 | 0.87 | PTGS2 (0.67) | PTGS2PTGS1 | |
| SCHEMBL7505153 | 0.85 | PTGS2 (0.62) | PTGS2PTGS1NR4A2RXRARXRB | |
| SCHEMBL9095581 | 0.85 | PTGS2 (0.62) | PTGS2PTGS1NR4A2RXRARXRB | |
| SCHEMBL5732857 | 0.85 | RXRA (0.62) | PTGS2PTGS1NR4A2RXRARXRB | |
| SCHEMBL5732397 | 0.85 | RXRA (0.62) | PTGS2PTGS1NR4A2RXRARXRB | |
| SCHEMBL7574288 | 0.85 | PTGS2 (0.61) | PTGS2PTGS1NR4A2RXRARXRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0825989-A1 | SUBSTITUTED OXAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1998-03-04 | — | — | EP | disclosed |
| US-5719163-A | ARTHRITIS | G.D. SEARLE & CO. (US) | 1998-02-17 | — | — | US | disclosed |
| WO-1996036617-A1 | SUBSTITUTED OXAZOLES FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-11-21 | — | — | WO | disclosed |
| EP-0699192-A1 | SUBSTITUTED OXAZOLYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-03-06 | — | — | EP | disclosed |
| WO-1994027980-A1 | SUBSTITUTED OXAZOLYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1994-12-08 | — | — | WO | disclosed |