Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.62 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.62 |
| ▸ | APEX1 | P27695 | 1/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.62 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.62 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.62 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.57 |
| ▸ | HTR1A | P08908 | 4/20 | 0.54 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.54 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.54 |
| ▸ | DRD2 | P14416 | 1/20 | 0.54 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.54 |
| ▸ | DRD4 | P21917 | 1/20 | 0.54 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.54 |
| ▸ | FPR3 | P25089 | 1/20 | 0.54 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.54 |
| ▸ | HTR1D | P28221 | 1/20 | 0.54 |
| ▸ | HTR1B | P28222 | 1/20 | 0.54 |
| ▸ | GPR183 | P32249 | 1/20 | 0.54 |
| ▸ | HTR7 | P34969 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8555864 | 1.00 | KDM4E (0.62) | KDM4EALOX15APEX1KMT2AHSD17B10 | |
| SCHEMBL8555542 | 0.93 | TDP1 (0.71) | KDM4EALOX15APEX1KMT2AHSD17B10 | |
| SCHEMBL9229535 | 0.91 | SLC6A4 (0.64) | KDM4EALOX15APEX1KMT2AHSD17B10 | |
| SCHEMBL8871408 | 0.89 | TDP1 (0.58) | KDM4EALOX15APEX1KMT2AHSD17B10 | |
| SCHEMBL8554060 | 0.86 | KDM4E (0.63) | KDM4EALOX15APEX1KMT2AHSD17B10 | |
| SCHEMBL9581872 | 0.83 | TDP1 (0.84) | KDM4EALOX15APEX1KMT2AHSD17B10 | |
| SCHEMBL9582285 | 0.82 | TDP1 (0.83) | KDM4EALOX15APEX1KMT2AHSD17B10 | |
| SCHEMBL9581279 | 0.82 | TDP1 (0.71) | KDM4EALOX15APEX1KMT2AHSD17B10 | |
| SCHEMBL9581909 | 0.81 | HTR1A (0.74) | KDM4EALOX15APEX1KMT2AHSD17B10 | |
| SCHEMBL9581828 | 0.80 | TDP1 (0.80) | KDM4EALOX15APEX1KMT2AHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0683166-B1 | 3-Indolylpiperidines | MERCK PATENT GMBH (DE) | 1998-10-28 | — | — | EP | disclosed |
| EP-0683166-A1 | 3-Indolylpiperidines | MERCK PATENT GmbH (DE) | 1995-11-22 | — | — | EP | disclosed |