Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.71 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.71 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.71 |
| ▸ | APEX1 | P27695 | 1/20 | 0.71 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.71 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.71 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.59 |
| ▸ | HTR1A | P08908 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 1/20 | 0.59 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.59 |
| ▸ | DRD2 | P14416 | 1/20 | 0.59 |
| ▸ | TSHR | P16473 | 1/20 | 0.59 |
| ▸ | DRD4 | P21917 | 1/20 | 0.59 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.59 |
| ▸ | DRD3 | P35462 | 1/20 | 0.59 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.56 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.56 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.56 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8554060 | 0.93 | KDM4E (0.63) | TDP1KDM4EALOX15APEX1KMT2A | |
| SCHEMBL8555864 | 0.93 | KDM4E (0.62) | TDP1KDM4EALOX15APEX1KMT2A | |
| SCHEMBL8552552 | 0.93 | KDM4E (0.62) | TDP1KDM4EALOX15APEX1KMT2A | |
| SCHEMBL9581872 | 0.90 | TDP1 (0.84) | TDP1KDM4EALOX15APEX1KMT2A | |
| SCHEMBL9581279 | 0.89 | TDP1 (0.71) | TDP1KDM4EALOX15APEX1KMT2A | |
| SCHEMBL9582285 | 0.89 | TDP1 (0.83) | TDP1KDM4EALOX15APEX1KMT2A | |
| SCHEMBL9581828 | 0.87 | TDP1 (0.80) | TDP1KDM4EALOX15APEX1KMT2A | |
| SCHEMBL9581893 | 0.86 | TDP1 (0.72) | TDP1KDM4EALOX15APEX1KMT2A | |
| SCHEMBL8555961 | 0.84 | HTR1A (0.68) | TDP1KDM4EALOX15APEX1KMT2A | |
| SCHEMBL8554164 | 0.83 | DRD2 (0.69) | TDP1CYP1A2CYP3A4HTR1AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0683166-B1 | 3-Indolylpiperidines | MERCK PATENT GMBH (DE) | 1998-10-28 | — | — | EP | disclosed |
| EP-0683166-A1 | 3-Indolylpiperidines | MERCK PATENT GmbH (DE) | 1995-11-22 | — | — | EP | disclosed |