Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SNCA | P37840 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.34 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.33 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.33 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8305671 | 0.89 | SNCA (0.38) | SNCAKMT2AL3MBTL1ADRB2ADRB1 | |
| SCHEMBL8299788 | 0.89 | SNCA (0.38) | SNCAKMT2AL3MBTL1ADRB2ADRB1 | |
| SCHEMBL8811940 | 0.87 | — | — | |
| SCHEMBL8603296 | 0.83 | ALDH1A1 (0.42) | KMT2AALDH1A1MEN1NPC1RAB9A | |
| SCHEMBL8305094 | 0.83 | SNCA (0.43) | SNCAKMT2AEPHX1ADRB2ADRB1 | |
| SCHEMBL8652713 | 0.82 | EPHX1 (0.36) | SNCAKMT2AEPHX1ADRB2ADRB1 | |
| SCHEMBL8437403 | 0.80 | SNCA (0.39) | SNCAKMT2AADRB2ADRB1ADRB3 | |
| SCHEMBL8438716 | 0.79 | MAPT (0.43) | KMT2AMEN1SMN1; SMN2 | |
| SCHEMBL27500418 | 0.79 | EPHX1 (0.34) | SNCAEPHX1ADRB2ADRB1ADRB3 | |
| SCHEMBL8593228 | 0.79 | SNCA (0.37) | SNCAKMT2AEPHX1ADRB2ADRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0869943-A1 | MONOCYCLIC BETA-LACTAME DERIVATIVES FOR TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 1998-10-14 | — | — | EP | disclosed |
| WO-1997021675-A1 | MONOCYCLIC BETA-LACTAME DERIVATIVES FOR TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 1997-06-19 | — | — | WO | disclosed |
| WO-1997002242-A1 | AZETIDINONE DERIVATIVES FOR THE TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 1997-01-23 | — | — | WO | disclosed |