Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRB | P24530 | 11/20 | 0.53 |
| ▸ | EDNRA | P25101 | 7/20 | 0.53 |
| ▸ | MAPT | P10636 | 4/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8549316 | 0.95 | EDNRB (0.52) | EDNRBEDNRAMAPTMEN1KMT2A | |
| SCHEMBL8547864 | 0.94 | EDNRB (0.49) | EDNRBEDNRAMAPTGRIN1GRIN2B | |
| SCHEMBL8551476 | 0.93 | EDNRB (0.48) | EDNRBEDNRAMAPTKDM4ENPSR1 | |
| SCHEMBL8550887 | 0.90 | EDNRB (0.58) | EDNRBEDNRAMAPTMEN1KMT2A | |
| SCHEMBL8548416 | 0.90 | EDNRB (0.50) | EDNRBEDNRAMAPTMEN1KMT2A | |
| SCHEMBL8548187 | 0.89 | EDNRB (0.46) | EDNRBEDNRAMAPTMEN1KMT2A | |
| SCHEMBL8548858 | 0.88 | EDNRB (0.45) | EDNRBEDNRAMAPTKDM4ENPSR1 | |
| SCHEMBL8550960 | 0.88 | EDNRB (0.66) | EDNRBEDNRAMAPTMEN1KMT2A | |
| SCHEMBL8552564 | 0.88 | EDNRB (0.66) | EDNRBEDNRATP53POLB | |
| SCHEMBL8550229 | 0.87 | EDNRB (0.48) | EDNRBEDNRAMAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0863898-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | MERCK PATENT GmbH (DE) | 1998-09-16 | — | — | EP | disclosed |
| WO-1997019077-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | MERCK Patent Gesellschaft mit beschränkter Haftung (DE) | 1997-05-29 | — | — | WO | disclosed |