Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRB | P24530 | 7/20 | 0.43 |
| ▸ | ELANE | P08246 | 2/20 | 0.40 |
| ▸ | F2 | P00734 | 1/20 | 0.40 |
| ▸ | PLAU | P00749 | 1/20 | 0.40 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | EDNRA | P25101 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8553066 | 0.91 | EDNRB (0.43) | EDNRBMAPTALDH1A1GAAHTT | |
| SCHEMBL8552494 | 0.90 | EDNRB (0.49) | EDNRBELANEF2PLAUCTRB1 | |
| SCHEMBL8552610 | 0.89 | EDNRB (0.46) | EDNRBELANEMAPTALDH1A1GAA | |
| SCHEMBL8548293 | 0.88 | EDNRB (0.45) | EDNRBMAPTALDH1A1GAAEDNRA | |
| SCHEMBL8551802 | 0.88 | EDNRB (0.39) | EDNRBELANEF2PLAUCTRB1 | |
| SCHEMBL8548809 | 0.87 | EDNRB (0.54) | EDNRBELANEF2PLAUCTRB1 | |
| SCHEMBL8552520 | 0.87 | EDNRB (0.46) | EDNRBELANEF2PLAUCTRB1 | |
| SCHEMBL8552500 | 0.87 | EDNRB (0.57) | EDNRBMAPTALDH1A1GAAEDNRA | |
| SCHEMBL8547962 | 0.86 | EDNRB (0.43) | EDNRBMAPTALDH1A1GAASMN1; SMN2 | |
| SCHEMBL8548911 | 0.85 | EDNRB (0.46) | EDNRBELANEF2PLAUCTRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0863898-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | MERCK PATENT GmbH (DE) | 1998-09-16 | — | — | EP | disclosed |
| WO-1997019077-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | MERCK Patent Gesellschaft mit beschränkter Haftung (DE) | 1997-05-29 | — | — | WO | disclosed |