Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRB | P24530 | 11/20 | 0.51 |
| ▸ | EDNRA | P25101 | 5/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8551621 | 0.94 | EDNRB (0.47) | EDNRBEDNRAMAPT | |
| SCHEMBL8550898 | 0.92 | EDNRB (0.47) | EDNRBEDNRATP53 | |
| SCHEMBL8551944 | 0.92 | EDNRB (0.46) | EDNRBEDNRA | |
| SCHEMBL8550952 | 0.92 | EDNRB (0.46) | EDNRBEDNRAKDM4EALDH1A1 | |
| SCHEMBL8552610 | 0.90 | EDNRB (0.46) | EDNRBEDNRAHSD17B10MAPTKDM4E | |
| SCHEMBL8553066 | 0.88 | EDNRB (0.43) | EDNRBEDNRAMAPTKDM4EALDH1A1 | |
| SCHEMBL8548216 | 0.88 | EDNRB (0.65) | EDNRBEDNRATP53 | |
| SCHEMBL8550887 | 0.86 | EDNRB (0.58) | EDNRBEDNRANPC1MAPTKDM4E | |
| SCHEMBL8549381 | 0.85 | EDNRB (0.43) | EDNRBEDNRAHSD17B10MAPTKDM4E | |
| SCHEMBL8547955 | 0.83 | EDNRB (0.43) | EDNRBEDNRAKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0863898-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | MERCK PATENT GmbH (DE) | 1998-09-16 | — | — | EP | disclosed |
| WO-1997019077-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | MERCK Patent Gesellschaft mit beschränkter Haftung (DE) | 1997-05-29 | — | — | WO | disclosed |