Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.43 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.41 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.40 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8553852 | 0.80 | HTT (0.45) | LMNATHRBMAPK1MEN1KMT2A | |
| SCHEMBL4121758 | 0.79 | SMN1; SMN2 (0.57) | NPSR1MEN1KMT2AHTTGRIN2B | |
| SCHEMBL8993974 | 0.77 | SMN1; SMN2 (0.54) | NPSR1MEN1KMT2AHTTGRIN2B | |
| SCHEMBL8553111 | 0.77 | SMN1; SMN2 (0.56) | NPSR1MEN1KMT2AHTTGRIN2B | |
| SCHEMBL8626081 | 0.76 | SMN1; SMN2 (0.51) | MEN1KMT2AALDH1A1HTTGRIN2B | |
| SCHEMBL8551784 | 0.74 | HTT (0.46) | LMNAMAPTNPSR1MEN1KMT2A | |
| SCHEMBL1206740 | 0.74 | SMN1; SMN2 (0.51) | NPSR1MEN1KMT2AHTTGRIN2B | |
| SCHEMBL29060008 | 0.74 | SMN1; SMN2 (0.52) | NPSR1MEN1KMT2AHTTGRIN2B | |
| SCHEMBL29060009 | 0.74 | SMN1; SMN2 (0.52) | NPSR1MEN1KMT2AHTTGRIN2B | |
| SCHEMBL18551726 | 0.74 | SMN1; SMN2 (0.52) | NPSR1MEN1KMT2AHTTGRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0858457-A1 | 5-MEMBERED HETEROCYCLES, PHARMACEUTICAL AGENTS CONTAINING SAID COMPOUNDS AND THE USE THEREOF AND METHODS OF PRODUCING THEM | Dr. Karl Thomae GmbH (DE) | 1998-08-19 | — | — | EP | disclosed |
| WO-1997015567-A1 | 5-MEMBERED HETEROCYCLES, PHARMACEUTICAL AGENTS CONTAINING SAID COMPOUNDS AND THE USE THEREOF AND METHODS OF PRODUCING THEM | DR. KARL THOMAE GMBH (DE) | 1997-05-01 | — | — | WO | disclosed |