Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 4/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.42 |
| ▸ | GRIN2B | Q13224 | 7/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | FLT3 | P36888 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8551545 | 0.90 | ENPP2 (0.42) | ENPP2NPC1SMN1; SMN2RAB9AMEN1 | |
| SCHEMBL8551127 | 0.85 | LMNA (0.45) | HTTENPP2NPC1SMN1; SMN2RAB9A | |
| SCHEMBL8553111 | 0.80 | SMN1; SMN2 (0.56) | HTTNPC1SMN1; SMN2RAB9AMEN1 | |
| SCHEMBL8553852 | 0.78 | HTT (0.45) | HTTENPP2NPC1SMN1; SMN2RAB9A | |
| Bromide SCHEMBL8551319 | 0.78 | POLB (0.44) | HTTMEN1KMT2AALDH1A1 | |
| SCHEMBL8626081 | 0.77 | SMN1; SMN2 (0.51) | HTTNPC1SMN1; SMN2RAB9AMEN1 | |
| SCHEMBL8552625 | 0.74 | LMNA (0.46) | HTTENPP2MEN1KMT2ALMNA | |
| SCHEMBL23201424 | 0.74 | SMN1; SMN2 (0.57) | HTTNPC1SMN1; SMN2RAB9AMEN1 | |
| SCHEMBL8551494 | 0.73 | PRMT5 (0.48) | HTTNPC1SMN1; SMN2RAB9AMEN1 | |
| Hydrochloric Acid SCHEMBL8549386 | 0.73 | POLB (0.48) | HTTNPC1SMN1; SMN2RAB9AKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0858457-A1 | 5-MEMBERED HETEROCYCLES, PHARMACEUTICAL AGENTS CONTAINING SAID COMPOUNDS AND THE USE THEREOF AND METHODS OF PRODUCING THEM | Dr. Karl Thomae GmbH (DE) | 1998-08-19 | — | — | EP | disclosed |
| WO-1997015567-A1 | 5-MEMBERED HETEROCYCLES, PHARMACEUTICAL AGENTS CONTAINING SAID COMPOUNDS AND THE USE THEREOF AND METHODS OF PRODUCING THEM | DR. KARL THOMAE GMBH (DE) | 1997-05-01 | — | — | WO | disclosed |