Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | ENPP2 | Q13822 | 3/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | GRIN2B | Q13224 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8552625 | 0.80 | LMNA (0.46) | HTTENPP2GRIN2BMEN1KMT2A | |
| Bromide SCHEMBL8593328 | 0.80 | SMYD3 (0.38) | SMN1; SMN2 | |
| SCHEMBL8553111 | 0.79 | SMN1; SMN2 (0.56) | HTTSMN1; SMN2NPC1RAB9AGRIN2B | |
| SCHEMBL8551784 | 0.78 | HTT (0.46) | HTTENPP2SMN1; SMN2NPC1RAB9A | |
| SCHEMBL8626081 | 0.77 | SMN1; SMN2 (0.51) | HTTSMN1; SMN2NPC1RAB9AGRIN2B | |
| SCHEMBL8552781 | 0.74 | LMNA (0.47) | HTTENPP2SMN1; SMN2NPC1RAB9A | |
| SCHEMBL23201424 | 0.73 | SMN1; SMN2 (0.57) | HTTSMN1; SMN2NPC1RAB9AGRIN2B | |
| SCHEMBL2857988 | 0.73 | HTT (0.62) | HTTENPP2SMN1; SMN2NPC1RAB9A | |
| SCHEMBL7137790 | 0.71 | SMN1; SMN2 (0.65) | HTTENPP2SMN1; SMN2NPC1RAB9A | |
| SCHEMBL658800 | 0.70 | LTA4H (0.59) | MEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0858457-A1 | 5-MEMBERED HETEROCYCLES, PHARMACEUTICAL AGENTS CONTAINING SAID COMPOUNDS AND THE USE THEREOF AND METHODS OF PRODUCING THEM | Dr. Karl Thomae GmbH (DE) | 1998-08-19 | — | — | EP | disclosed |
| WO-1997015567-A1 | 5-MEMBERED HETEROCYCLES, PHARMACEUTICAL AGENTS CONTAINING SAID COMPOUNDS AND THE USE THEREOF AND METHODS OF PRODUCING THEM | DR. KARL THOMAE GMBH (DE) | 1997-05-01 | — | — | WO | disclosed |