Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 8/20 | 0.54 |
| ▸ | CYP11B2 | P19099 | 9/20 | 0.36 |
| ▸ | CYP11B1 | P15538 | 8/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.36 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.35 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.35 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.35 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.33 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.33 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2108142 | 0.89 | ALOX5 (0.51) | ALOX5CYP11B2CYP11B1CYP1A2CYP17A1 | |
| SCHEMBL9127952 | 0.87 | ALOX5 (0.54) | ALOX5CYP11B2CYP11B1CYP1A2CYP17A1 | |
| SCHEMBL2108607 | 0.81 | ALOX5 (0.44) | ALOX5TRIM24 | |
| SCHEMBL8557163 | 0.81 | ALOX5 (0.56) | ALOX5CYP11B2CYP11B1CYP1A2CYP17A1 | |
| SCHEMBL9125544 | 0.79 | ALOX5 (0.57) | ALOX5CYP11B2CYP11B1CYP1A2CYP17A1 | |
| SCHEMBL8552201 | 0.79 | ALOX5 (0.52) | ALOX5CYP11B2CYP11B1CYP1A2CYP17A1 | |
| SCHEMBL8554091 | 0.79 | ALOX5 (0.40) | ALOX5 | |
| SCHEMBL9126763 | 0.76 | ALOX5 (0.70) | ALOX5CYP11B2CYP11B1CYP1A2CYP17A1 | |
| SCHEMBL9435738 | 0.75 | ALOX5 (0.42) | ALOX5CYP11B2CYP11B1 | |
| SCHEMBL4603569 | 0.75 | ALOX5 (0.42) | ALOX5CYP11B2CYP11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0623614-B1 | 4-Aryl-4-hydroxy-tetrahydropyrans and 3-aryl-3-hydroxy-tetrahydrofurans as 5-lipoxygenase inhibitors | ZENECA LTD (GB) | 1998-02-25 | — | — | EP | disclosed |
| US-5512594-A | ADMINISTERING TO TREAT A MEDICAL CONDITION MEDIATED BY ONE OR MORE LEUKOTRIENES | ZENECA LIMITED (GB) | 1996-04-30 | — | — | US | disclosed |
| US-5478842-A | Antiinflammatory agents, antiallergens, drugs for treatment of diseases mediated by leukotrienes | ZENECA LIMITED (GB) | 1995-12-26 | — | — | US | disclosed |
| US-5478843-A | Administering as inhibitors of the enzyme 5-lipoxygenase | ZENECA LIMITED (GB) | 1995-12-26 | — | — | US | disclosed |
| WO-1995004055-A1 | THIAZOLE DERIVATIVES AS LIPOXYGENASE INHIBITORS | ZENECA LIMITED (GB) | 1995-02-09 | — | — | WO | disclosed |
| EP-0636624-A1 | Thiazole derivatives as lipoxygenase inhibitors | ZENECA LIMITED (GB) | 1995-02-01 | — | — | EP | disclosed |
| EP-0623614-A1 | 4-Aryl-4-hydroxy-tetrahydropyrans and 3-aryl-3-hydroxy-tetrahydrofurans as 5-lipoxygenase inhibitors | ZENECA LIMITED (GB) | 1994-11-09 | — | — | EP | disclosed |