Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 17/20 | 0.56 |
| ▸ | CSF1R | P07333 | 2/20 | 0.56 |
| ▸ | MET | P08581 | 2/20 | 0.54 |
| ▸ | AURKA | O14965 | 1/20 | 0.54 |
| ▸ | TEK | Q02763 | 1/20 | 0.54 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.54 |
| ▸ | EGFR | P00533 | 1/20 | 0.53 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.53 |
| ▸ | RET | P07949 | 1/20 | 0.50 |
| ▸ | KIF5B | P33176 | 1/20 | 0.50 |
| ▸ | BRAF | P15056 | 1/20 | 0.50 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.49 |
| ▸ | FLT4 | P35916 | 1/20 | 0.49 |
| ▸ | FLT3 | P36888 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8554076 | 0.92 | KDR (0.58) | KDRCSF1RMETAURKATEK | |
| SCHEMBL8554780 | 0.87 | KDR (0.66) | KDRCSF1RMETAURKATEK | |
| SCHEMBL8556665 | 0.85 | PDGFRA (0.59) | KDRMETAURKATEKAURKB | |
| SCHEMBL8556537 | 0.83 | KDR (0.61) | KDRCSF1RMETAURKATEK | |
| SCHEMBL409724 | 0.78 | MET (0.55) | KDRCSF1RMETAURKATEK | |
| SCHEMBL8554120 | 0.77 | PDGFRA (0.58) | KDRMETAURKATEKAURKB | |
| SCHEMBL14967551 | 0.77 | KDR (0.67) | KDRCSF1RMETAURKATEK | |
| SCHEMBL4410667 | 0.77 | MET (0.53) | KDRCSF1RMETAURKATEK | |
| SCHEMBL16673564 | 0.76 | BRAF (0.68) | BRAF | |
| SCHEMBL8554994 | 0.76 | PDGFRA (0.57) | KDRMETAURKATEKAURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0860433-A1 | QUINOLINE DERIVATIVES AND QUINAZOLINE DERIVATIVES INHIBITING AUTOPHOSPHORYLATION OF GROWTH FACTOR RECEPTOR ORIGINATING IN PLATELET AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME | KIRIN BEER KABUSHIKI KAISHA (JP) | 1998-08-26 | — | — | EP | claimed |