Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 15/20 | 0.58 |
| ▸ | CSF1R | P07333 | 3/20 | 0.58 |
| ▸ | MET | P08581 | 2/20 | 0.56 |
| ▸ | AURKA | O14965 | 1/20 | 0.56 |
| ▸ | TEK | Q02763 | 1/20 | 0.56 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.56 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.55 |
| ▸ | BRAF | P15056 | 2/20 | 0.54 |
| ▸ | RAF1 | P04049 | 2/20 | 0.52 |
| ▸ | RET | P07949 | 1/20 | 0.52 |
| ▸ | KIF5B | P33176 | 1/20 | 0.52 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.52 |
| ▸ | FLT4 | P35916 | 3/20 | 0.52 |
| ▸ | FLT3 | P36888 | 2/20 | 0.52 |
| ▸ | KIT | P10721 | 2/20 | 0.51 |
| ▸ | SRC | P12931 | 1/20 | 0.51 |
| ▸ | FLT1 | P17948 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8552819 | 0.92 | KDR (0.56) | KDRCSF1RMETAURKATEK | |
| SCHEMBL8554780 | 0.89 | KDR (0.66) | KDRCSF1RMETAURKATEK | |
| SCHEMBL8556537 | 0.85 | KDR (0.61) | KDRCSF1RMETAURKATEK | |
| SCHEMBL8554120 | 0.85 | PDGFRA (0.58) | KDRMETAURKATEKAURKB | |
| SCHEMBL14967551 | 0.78 | KDR (0.67) | KDRCSF1RMETAURKATEK | |
| SCHEMBL4410667 | 0.78 | MET (0.53) | KDRCSF1RMETAURKATEK | |
| SCHEMBL409724 | 0.78 | MET (0.55) | KDRCSF1RMETAURKATEK | |
| SCHEMBL7484941 | 0.77 | KDR (0.59) | KDRCSF1RMETAURKATEK | |
| SCHEMBL8556665 | 0.77 | PDGFRA (0.59) | KDRMETAURKATEKAURKB | |
| SCHEMBL18158553 | 0.77 | KDR (0.70) | KDRCSF1RPDGFRABRAFRAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0860433-A1 | QUINOLINE DERIVATIVES AND QUINAZOLINE DERIVATIVES INHIBITING AUTOPHOSPHORYLATION OF GROWTH FACTOR RECEPTOR ORIGINATING IN PLATELET AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME | KIRIN BEER KABUSHIKI KAISHA (JP) | 1998-08-26 | — | — | EP | claimed |