Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRCP | P42785 | 3/20 | 0.58 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.58 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.50 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.48 |
| ▸ | GID4 | Q8IVV7 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | BCHE | P06276 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9411108 | 0.86 | BCHE (0.64) | BCHE | |
| SCHEMBL8558602 | 0.86 | PRCP (0.52) | PRCPSLC22A1OPRM1CYP2D6TSHR | |
| Hydrochloric Acid SCHEMBL10802047 | 0.81 | PRCP (0.50) | PRCPSLC22A1OPRM1CYP2D6TSHR | |
| SCHEMBL9411172 | 0.81 | TBXA2R (0.67) | PRCPSLC22A1OPRM1BCHE | |
| SCHEMBL8554897 | 0.81 | SLC22A1 (0.63) | PRCPSLC22A1BCHE | |
| SCHEMBL10396230 | 0.78 | PRCP (0.63) | PRCPSLC22A1OPRM1OPRK1 | |
| SCHEMBL10348630 | 0.78 | KDM4E (0.66) | PRCPSLC22A1OPRM1BCHE | |
| SCHEMBL8556491 | 0.78 | PRCP (0.71) | PRCPSLC22A1OPRM1OPRK1GID4 | |
| SCHEMBL12859659 | 0.78 | PRCP (0.71) | PRCPSLC22A1OPRM1OPRK1GID4 | |
| SCHEMBL10348881 | 0.77 | KDM4E (0.63) | PRCPSLC22A1OPRM1BCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0617022-B1 | 6,7, dialkoxy-3,4-dihydroisoquinolin-8-ol, process for preparation thereof and process for preparation of 6,7-dialkoxy-1,2,3,4-tetrahydroisoquinolin-8-ol using the compound | BANYU PHARMA CO LTD (JP) | 1998-02-11 | — | — | EP | disclosed |
| US-4626591-A | Trans-dl-1-alkyl-6-alkoxy-1,2,3,4,4a,5,8,8a octa-hydroquinolines | ELI LILLY AND COMPANY (US) | 1986-12-02 | — | — | US | disclosed |
| US-4540787-A | Method of preparing trans-D1-1-alkyl-6-oxodecahydroquinolines | ELI LILLY AND COMPANY (US) | 1985-09-10 | — | — | US | disclosed |