Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 2/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 5/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | LMNA | P02545 | 4/20 | 0.46 |
| ▸ | NPC1 | O15118 | 5/20 | 0.44 |
| ▸ | RAB9A | P51151 | 5/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | HTR1D | P28221 | 6/20 | 0.42 |
| ▸ | HTR1B | P28222 | 5/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8549937 | 0.99 | DRD2 (0.46) | DRD2SLC6A4MEN1KMT2AMAPT | |
| SCHEMBL8552316 | 0.90 | NPC1 (0.54) | DRD2SLC6A4MEN1KMT2AMAPT | |
| SCHEMBL8547499 | 0.85 | HTR1D (0.46) | DRD2SLC6A4RAB9AHTR1DHTR1B | |
| SCHEMBL8553071 | 0.84 | KMT2A (0.47) | MEN1KMT2AMAPTLMNANPC1 | |
| SCHEMBL8548023 | 0.84 | DRD2 (0.50) | DRD2SLC6A4MEN1KMT2AMAPT | |
| SCHEMBL8551620 | 0.84 | DRD2 (0.48) | DRD2SLC6A4MEN1KMT2AMAPT | |
| SCHEMBL8702974 | 0.83 | DRD2 (0.53) | DRD2SLC6A4NPC1RAB9AHTR1D | |
| SCHEMBL7476227 | 0.83 | HTR1D (0.62) | DRD2HTR1DHTR1BCHRM2 | |
| SCHEMBL8590783 | 0.82 | DRD2 (0.46) | DRD2SLC6A4HTR1DHTR1BCHRM2 | |
| SCHEMBL7483296 | 0.82 | HTR1D (0.64) | DRD2HTR1DHTR1BCHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5792763-A | MIGRAINES; ANALGESICS; DISEASES LINKED TO DECREASED NEUROTRANMISSION OF SEROTONIN IN MAMMALS | ELI LILLY AND COMPANY (US) | 1998-08-11 | — | — | US | disclosed |
| EP-0835869-A2 | New serotonin 5-HT1F agonists | ELI LILLY AND COMPANY (US) | 1998-04-15 | — | — | EP | disclosed |