Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 9/20 | 0.47 |
| ▸ | MEN1 | O00255 | 8/20 | 0.47 |
| ▸ | MAPT | P10636 | 8/20 | 0.47 |
| ▸ | LMNA | P02545 | 4/20 | 0.47 |
| ▸ | NPC1 | O15118 | 11/20 | 0.43 |
| ▸ | RAB9A | P51151 | 11/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 5/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | PKM | P14618 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | CASP1 | P29466 | 2/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.41 |
| ▸ | RELA | Q04206 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8552316 | 0.88 | NPC1 (0.54) | KMT2AMEN1MAPTLMNANPC1 | |
| SCHEMBL8553073 | 0.84 | DRD2 (0.46) | KMT2AMEN1MAPTLMNANPC1 | |
| SCHEMBL8553184 | 0.84 | RAB9A (0.41) | NPC1RAB9ASMN1; SMN2TP53 | |
| SCHEMBL8548010 | 0.84 | DRD2 (0.40) | KMT2AMEN1MAPTKDM4EHPGD | |
| SCHEMBL8549937 | 0.84 | DRD2 (0.46) | KMT2AMEN1MAPTLMNANPC1 | |
| SCHEMBL8704365 | 0.83 | DRD2 (0.42) | KMT2AMEN1MAPTLMNANPC1 | |
| SCHEMBL7476220 | 0.82 | HTR1D (0.54) | — | |
| SCHEMBL8552293 | 0.82 | LMNA (0.42) | KMT2AMEN1MAPTLMNAHSD17B10 | |
| SCHEMBL8723743 | 0.80 | MAPT (0.47) | KMT2AMEN1MAPTLMNANPC1 | |
| SCHEMBL8547967 | 0.78 | MAPT (0.46) | KMT2AMEN1MAPTLMNANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5792763-A | MIGRAINES; ANALGESICS; DISEASES LINKED TO DECREASED NEUROTRANMISSION OF SEROTONIN IN MAMMALS | ELI LILLY AND COMPANY (US) | 1998-08-11 | — | — | US | disclosed |
| WO-1998015545-A1 | NEW SEROTONIN 5-HT1F AGONISTS | ELI LILLY AND COMPANY (US) | 1998-04-16 | — | — | WO | disclosed |
| EP-0835869-A2 | New serotonin 5-HT1F agonists | ELI LILLY AND COMPANY (US) | 1998-04-15 | — | — | EP | disclosed |