Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 11/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 7/20 | 0.36 |
| ▸ | TRIM24 | O15164 | 3/20 | 0.35 |
| ▸ | BRD4 | O60885 | 2/20 | 0.33 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.33 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.32 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.32 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.32 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.32 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8554290 | 0.75 | CYP11B1 (0.39) | CYP11B1CYP11B2BRD4GABRG2GABRB3 | |
| SCHEMBL14779688 | 0.75 | CYP11B1 (0.39) | CYP11B1CYP11B2BRD4CYP17A1CYP1A2 | |
| SCHEMBL17724402 | 0.75 | CYP11B1 (0.39) | CYP11B1CYP11B2BRD4GABRG2GABRB3 | |
| SCHEMBL8553555 | 0.71 | CYP11B1 (0.42) | CYP11B1CYP11B2TRIM24BRD4CREBBP | |
| SCHEMBL17713696 | 0.70 | JAK2 (0.35) | CYP11B1CYP11B2BRD4GABRG2GABRB3 | |
| SCHEMBL8557973 | 0.68 | NOTUM (0.49) | TRPV1 | |
| SCHEMBL28699718 | 0.68 | BRPF1 (0.36) | BRD4 | |
| SCHEMBL8600438 | 0.67 | TRIM24 (0.53) | CYP11B1CYP11B2TRIM24BRD4CREBBP | |
| SCHEMBL16132463 | 0.66 | BRD4 (0.44) | CYP11B1CYP11B2BRD4CREBBPCYP17A1 | |
| SCHEMBL17713772 | 0.66 | HTR2A (0.37) | CYP11B1CYP11B2BRD4CYP17A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0623614-B1 | 4-Aryl-4-hydroxy-tetrahydropyrans and 3-aryl-3-hydroxy-tetrahydrofurans as 5-lipoxygenase inhibitors | ZENECA LTD (GB) | 1998-02-25 | — | — | EP | disclosed |
| US-5512594-A | ADMINISTERING TO TREAT A MEDICAL CONDITION MEDIATED BY ONE OR MORE LEUKOTRIENES | ZENECA LIMITED (GB) | 1996-04-30 | — | — | US | disclosed |
| US-5478842-A | Antiinflammatory agents, antiallergens, drugs for treatment of diseases mediated by leukotrienes | ZENECA LIMITED (GB) | 1995-12-26 | — | — | US | disclosed |
| WO-1994025453-A1 | 4-ARYL-4-HYDROXY-TETRAHYDROPYRANS AND 3-ARYL-3-HYDROXY-TETRAHYDROFURANS AS 5-LIPOXYGENASE INHIBITORS | ZENECA LIMITED (GB) | 1994-11-10 | — | — | WO | disclosed |
| EP-0623614-A1 | 4-Aryl-4-hydroxy-tetrahydropyrans and 3-aryl-3-hydroxy-tetrahydrofurans as 5-lipoxygenase inhibitors | ZENECA LIMITED (GB) | 1994-11-09 | — | — | EP | disclosed |