Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 2/20 | 0.49 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.49 |
| ▸ | F2R | P25116 | 5/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | HTR1D | P28221 | 7/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | HTR1B | P28222 | 5/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.41 |
| ▸ | NPY2R | P49146 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8548023 | 0.89 | DRD2 (0.50) | DRD2SLC6A4HTR1DKMT2AHTR1B | |
| SCHEMBL8552547 | 0.87 | DRD2 (0.47) | DRD2SLC6A4HTR1DKMT2AHTR1B | |
| SCHEMBL8548076 | 0.86 | DRD2 (0.47) | DRD2SLC6A4HTR1DHTR1BCHRM2 | |
| SCHEMBL8703019 | 0.85 | DRD2 (0.53) | DRD2SLC6A4NPC1RAB9AKDM4E | |
| SCHEMBL8547861 | 0.83 | DRD2 (0.50) | DRD2SLC6A4F2R | |
| SCHEMBL7479962 | 0.83 | HTR1D (0.62) | DRD2HTR1DHTR1BCHRM2 | |
| SCHEMBL8702974 | 0.82 | DRD2 (0.53) | DRD2SLC6A4NPC1RAB9AHTR1D | |
| SCHEMBL8708757 | 0.81 | DRD2 (0.53) | DRD2SLC6A4ALDH1A1 | |
| SCHEMBL8552559 | 0.80 | DRD2 (0.47) | DRD2SLC6A4HTR1DALDH1A1HTR1B | |
| SCHEMBL8553349 | 0.80 | DRD2 (0.47) | DRD2SLC6A4NPC1SMN1; SMN2HTR1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5792763-A | MIGRAINES; ANALGESICS; DISEASES LINKED TO DECREASED NEUROTRANMISSION OF SEROTONIN IN MAMMALS | ELI LILLY AND COMPANY (US) | 1998-08-11 | — | — | US | disclosed |
| WO-1998015545-A1 | NEW SEROTONIN 5-HT1F AGONISTS | ELI LILLY AND COMPANY (US) | 1998-04-16 | — | — | WO | disclosed |
| EP-0835869-A2 | New serotonin 5-HT1F agonists | ELI LILLY AND COMPANY (US) | 1998-04-15 | — | — | EP | disclosed |