Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 1/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.43 |
| ▸ | STK17B | O94768 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | CHRNA7 | P36544 | 4/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.41 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.41 |
| ▸ | TCF7L2 | Q9NQB0 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HTR1D | P28221 | 1/20 | 0.40 |
| ▸ | ACKR3 | P25106 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8703019 | 0.84 | DRD2 (0.53) | DRD2SLC6A4KDM4ENPC1 | |
| SCHEMBL8552559 | 0.83 | DRD2 (0.47) | DRD2SLC6A4ALDH1A1HTR1D | |
| SCHEMBL8550182 | 0.83 | DRD2 (0.47) | DRD2SLC6A4HTR1D | |
| SCHEMBL8552297 | 0.82 | DRD2 (0.48) | DRD2SLC6A4 | |
| SCHEMBL8702974 | 0.81 | DRD2 (0.53) | DRD2SLC6A4KDM4ENPC1KCNH2 | |
| SCHEMBL7480397 | 0.81 | HTR1D (0.61) | DRD2HTR1D | |
| SCHEMBL8546540 | 0.81 | DRD2 (0.51) | DRD2SLC6A4KDM4EEPHX2 | |
| SCHEMBL8546639 | 0.81 | SMN1; SMN2 (0.48) | DRD2SLC6A4KDM4EEPHX2ALDH1A1 | |
| SCHEMBL8553277 | 0.80 | DRD2 (0.49) | DRD2SLC6A4KDM4EALDH1A1HPGD | |
| SCHEMBL8708757 | 0.80 | DRD2 (0.53) | DRD2SLC6A4ALDH1A1LMNATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5792763-A | MIGRAINES; ANALGESICS; DISEASES LINKED TO DECREASED NEUROTRANMISSION OF SEROTONIN IN MAMMALS | ELI LILLY AND COMPANY (US) | 1998-08-11 | — | — | US | disclosed |
| EP-0835869-A2 | New serotonin 5-HT1F agonists | ELI LILLY AND COMPANY (US) | 1998-04-15 | — | — | EP | disclosed |