Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 17/20 | 0.52 |
| ▸ | PDE4A | P27815 | 8/20 | 0.52 |
| ▸ | PDE4B | Q07343 | 8/20 | 0.52 |
| ▸ | PDE4C | Q08493 | 8/20 | 0.52 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 2/20 | 0.39 |
| ▸ | JAK1 | P23458 | 2/20 | 0.39 |
| ▸ | TYK2 | P29597 | 2/20 | 0.39 |
| ▸ | JAK3 | P52333 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8557512 | 0.94 | PDE4D (0.51) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL8558524 | 0.87 | PDE4D (0.45) | PDE4DPDE4APDE4BPDE4CCYP11B1 | |
| SCHEMBL7355149 | 0.73 | PDE4D (0.48) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL7359952 | 0.71 | PDE4D (0.67) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL7362470 | 0.71 | PDE4D (0.76) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL7354074 | 0.71 | PDE4D (0.76) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL7361858 | 0.71 | PDE4D (0.76) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL7355461 | 0.71 | PDE4D (0.56) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL7360858 | 0.70 | PDE4D (0.47) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL7360860 | 0.70 | PDE4D (0.47) | PDE4DPDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0741707-B1 | SUBSTITUTED AROMATIC COMPOUNDS AS c.AMP PHOSPHODIESTERASE- AND TNF-INHIBITORS | RHONE POULENC RORER LTD (GB) | 1998-04-01 | — | — | EP | claimed |