Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 13/20 | 0.45 |
| ▸ | PDE4A | P27815 | 13/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 8/20 | 0.42 |
| ▸ | PDE4C | Q08493 | 8/20 | 0.42 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.39 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.38 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.38 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8553863 | 0.87 | PDE4D (0.52) | PDE4DPDE4APDE4BPDE4CCYP11B1 | |
| SCHEMBL8557512 | 0.81 | PDE4D (0.51) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL6073147 | 0.79 | PDE4D (0.52) | PDE4DPDE4APDE4BPDE4CABCB11 | |
| SCHEMBL7353130 | 0.72 | PDE4D (0.65) | PDE4DPDE4APDE4BPDE4CABCB11 | |
| SCHEMBL7356144 | 0.72 | PDE4D (0.66) | PDE4DPDE4APDE4BPDE4CABCB11 | |
| SCHEMBL6588088 | 0.71 | PDE4D (0.42) | PDE4DPDE4APDE4BPDE4CABCB11 | |
| SCHEMBL6588109 | 0.70 | PDE4D (0.79) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL31208529 | 0.69 | ATR (0.46) | PDE4DPDE4APDE4BPDE4CCYP11B1 | |
| SCHEMBL3673426 | 0.69 | ATR (0.46) | PDE4DPDE4APDE4BPDE4CCYP11B1 | |
| SCHEMBL31208548 | 0.69 | ATR (0.46) | PDE4DPDE4APDE4BPDE4CCYP11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0741707-B1 | SUBSTITUTED AROMATIC COMPOUNDS AS c.AMP PHOSPHODIESTERASE- AND TNF-INHIBITORS | RHONE POULENC RORER LTD (GB) | 1998-04-01 | — | — | EP | claimed |