Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 16/20 | 0.51 |
| ▸ | PDE4B | Q07343 | 11/20 | 0.44 |
| ▸ | PDE4A | P27815 | 8/20 | 0.44 |
| ▸ | PDE4C | Q08493 | 8/20 | 0.44 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8553863 | 0.94 | PDE4D (0.52) | PDE4DPDE4BPDE4APDE4C | |
| SCHEMBL8558524 | 0.81 | PDE4D (0.45) | PDE4DPDE4BPDE4APDE4C | |
| SCHEMBL12970631 | 0.70 | PARP15 (0.54) | PDE4DPDE4BPDE4APDE4CTBK1 | |
| SCHEMBL7352455 | 0.70 | PDE4D (0.70) | PDE4DPDE4BPDE4APDE4C | |
| SCHEMBL7354173 | 0.70 | PDE4D (0.83) | PDE4DPDE4BPDE4APDE4C | |
| SCHEMBL885060 | 0.69 | PDE4D (0.83) | PDE4DPDE4BPDE4APDE4C | |
| Hydrochloric Acid SCHEMBL8479616 | 0.67 | MKNK1 (0.48) | PDE4DPDE4BPDE4APDE4C | |
| SCHEMBL7360943 | 0.67 | PDE4D (0.66) | PDE4DPDE4BPDE4APDE4C | |
| SCHEMBL7355149 | 0.66 | PDE4D (0.48) | PDE4DPDE4BPDE4APDE4C | |
| SCHEMBL8554057 | 0.66 | PDE4A (0.64) | PDE4DPDE4BPDE4APDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0741707-B1 | SUBSTITUTED AROMATIC COMPOUNDS AS c.AMP PHOSPHODIESTERASE- AND TNF-INHIBITORS | RHONE POULENC RORER LTD (GB) | 1998-04-01 | — | — | EP | claimed |