Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 1/20 | 0.52 |
| ▸ | CA1 | P00915 | 1/20 | 0.52 |
| ▸ | CA2 | P00918 | 1/20 | 0.52 |
| ▸ | CA4 | P22748 | 1/20 | 0.52 |
| ▸ | CA6 | P23280 | 1/20 | 0.52 |
| ▸ | CA7 | P43166 | 1/20 | 0.52 |
| ▸ | TPMT | P51580 | 1/20 | 0.52 |
| ▸ | CA9 | Q16790 | 1/20 | 0.52 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.52 |
| ▸ | PDE4D | Q08499 | 10/20 | 0.50 |
| ▸ | PDE4A | P27815 | 9/20 | 0.50 |
| ▸ | PDE4B | Q07343 | 9/20 | 0.50 |
| ▸ | PDE4C | Q08493 | 9/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | TTR | P02766 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7363109 | 0.90 | PDE4D (0.42) | CA12CA1CA2CA4CA6 | |
| SCHEMBL7354542 | 0.85 | PDE4D (0.44) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL7358710 | 0.83 | AR (0.36) | CA12CA1CA2CA4CA6 | |
| SCHEMBL7363194 | 0.82 | MRGPRX4 (0.43) | RAB9A | |
| SCHEMBL7357205 | 0.80 | PDE4D (0.66) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL7362448 | 0.79 | ALDH1A1 (0.51) | PDE4DPDE4APDE4BPDE4CTSHR | |
| SCHEMBL7361951 | 0.79 | PDE4D (0.64) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL7361572 | 0.79 | PDE4D (0.68) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL8556184 | 0.78 | PDE4B (0.53) | CA12CA1CA2CA4CA6 | |
| SCHEMBL7357012 | 0.78 | PDE4D (0.44) | PDE4DPDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0741707-B1 | SUBSTITUTED AROMATIC COMPOUNDS AS c.AMP PHOSPHODIESTERASE- AND TNF-INHIBITORS | RHONE POULENC RORER LTD (GB) | 1998-04-01 | — | — | EP | disclosed |