Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | FDPS | P14324 | 1/20 | 0.43 |
| ▸ | AOX1 | Q06278 | 1/20 | 0.41 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | ALDH5A1 | P51649 | 1/20 | 0.41 |
| ▸ | ABAT | P80404 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.41 |
| ▸ | TTR | P02766 | 1/20 | 0.40 |
| ▸ | ALDH1A3 | P47895 | 1/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 7/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.38 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8553907 | 0.79 | CA12 (0.52) | TSHRTTRPDE4BLMNAHTT | |
| SCHEMBL7363109 | 0.79 | PDE4D (0.42) | TSHRPDE4BPDE4DPDE4APDE4C | |
| SCHEMBL7358878 | 0.78 | ALDH1A1 (0.51) | ALDH1A1TSHRFDPSAOX1TRIM24 | |
| SCHEMBL4637716 | 0.75 | ALDH1A1 (0.55) | ALDH1A1TSHRFDPSAOX1TRIM24 | |
| SCHEMBL22713946 | 0.75 | ALDH1A1 (0.68) | ALDH1A1TSHRFDPSAOX1TRIM24 | |
| SCHEMBL7359792 | 0.75 | ALDH1A1 (0.51) | ALDH1A1TSHRFDPSAOX1TRIM24 | |
| SCHEMBL7278324 | 0.74 | PDE4B (0.60) | ALDH1A1TSHRPDE4BPDE4DPDE3A | |
| SCHEMBL7288403 | 0.74 | PDE4B (0.60) | ALDH1A1TSHRPDE4BPDE4DPDE3A | |
| SCHEMBL7270844 | 0.74 | PDE4B (0.60) | ALDH1A1TSHRPDE4BPDE4DPDE3A | |
| SCHEMBL4637257 | 0.74 | ALDH1A1 (0.54) | ALDH1A1TSHRFDPSAOX1TRIM24 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0741707-B1 | SUBSTITUTED AROMATIC COMPOUNDS AS c.AMP PHOSPHODIESTERASE- AND TNF-INHIBITORS | RHONE POULENC RORER LTD (GB) | 1998-04-01 | — | — | EP | disclosed |
| EP-0741707-A1 | SUBSTITUTED AROMATIC COMPOUNDS AS c.AMP PHOSPHODIESTERASE- AND TNF-INHIBITORS | RHONE-POULENC RORER LIMITED (GB) | 1996-11-13 | — | — | EP | disclosed |
| WO-1995020578-A1 | SUBSTITUTED AROMATIC COMPOUNDS AS c.AMP PHOSPHODIESTERASE- AND TNF-INHIBITORS | RHONE-POULENC RORER LIMITED (GB) | 1995-08-03 | — | — | WO | disclosed |