SCHEMBL8554069

SCHEMBL8554069

BCOCCC1OCCc2cc(Br)ccc21

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 1/20 0.34
HTT P42858 1/20 0.34
HTR1D P28221 9/20 0.33
DRD2 P14416 7/20 0.33
HTR2A P28223 7/20 0.33
HTR1A P08908 5/20 0.33
DRD4 P21917 4/20 0.33
HTR1B P28222 2/20 0.32
THRB P10828 1/20 0.31
ALDH1A1 P00352 1/20 0.31
TAAR1 Q96RJ0 1/20 0.31
ADRA2A P08913 1/20 0.31
ADRA2B P18089 1/20 0.31
ADRA2C P18825 1/20 0.31
DRD1 P21728 1/20 0.31
ADRA1D P25100 1/20 0.31
ADRA1A P35348 1/20 0.31
ADRA1B P35368 1/20 0.31
DRD3 P35462 1/20 0.31
HTR2B P41595 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8549512 0.80 MAPT (0.38) MAPTHTTHTR1DDRD2HTR2A
SCHEMBL5088620 0.79 PNMT (0.41) MAPTHTTHTR1DDRD2HTR2A
SCHEMBL5090707 0.79 PNMT (0.41) MAPTHTTHTR1DDRD2HTR2A
SCHEMBL6811491 0.79 HTR1D (0.34) MAPTHTTHTR1DDRD2HTR2A
SCHEMBL5088651 0.79 HTR1D (0.36) MAPTHTTHTR1DDRD2HTR2A
SCHEMBL5092141 0.79 HTR1D (0.34) MAPTHTTHTR1DDRD2HTR2A
SCHEMBL6812993 0.79 HTR1D (0.36) MAPTHTTHTR1DDRD2HTR2A
SCHEMBL20699974 0.76 DRD1 (0.49) MAPTHTTHTR1DDRD2HTR2A
SCHEMBL20718641 0.76 MAPT (0.41) MAPTHTTDRD2HTR2AHTR1A
SCHEMBL28745705 0.74 MAPT (0.39) MAPTHTTHTR1DDRD2HTR2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0836599-A1 1,6-DISUBSTITUTED ISOCHROMANS FOR TREATMENT OF MIGRAINE HEADACHES PHARMACIA & UPJOHN COMPANY (US) 1998-04-22 EP disclosed