SCHEMBL8554243

SCHEMBL8554243

Nc1c(NC(=O)C23CCCN2CCC3)cnc2ccccc12

nearest known ligand 0.37

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
BCHE P06276 7/20 0.37
WNT3A P56704 2/20 0.35
KDM4E B2RXH2 1/20 0.35
PIM2 Q9P1W9 1/20 0.35
GAA P10253 1/20 0.35
SMN1; SMN2 Q16637 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8554648 0.81 KCNH2 (0.49) BCHEPIM2
SCHEMBL27891349 0.74 HSD17B10 (0.46) BCHEKDM4EGAASMN1; SMN2
SCHEMBL8554652 0.68 HSD17B10 (0.34) KDM4EGAASMN1; SMN2
SCHEMBL8554656 0.66 ADORA3 (0.42) KDM4EGAASMN1; SMN2
SCHEMBL18183187 0.65 KDM4E (0.50) BCHEKDM4ESMN1; SMN2
SCHEMBL10770309 0.64 NPC1 (0.51) KDM4EGAASMN1; SMN2
Acetic Acid SCHEMBL9382447 0.64 KDM4E (0.40) BCHEKDM4EGAASMN1; SMN2
SCHEMBL9838399 0.64 CSF1R (0.41) BCHEKDM4ESMN1; SMN2
SCHEMBL9836349 0.62 PTGS1 (0.61) GAA
SCHEMBL8554096 0.62 HRH3 (0.39) KDM4EGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0543307-B1 Nootropic agent SANWA KAGAKU KENKYUSHO CO (JP) 1998-05-06 EP claimed
US-5434165-A Nootropic agents, compositions of, and method of use thereof SANAWA KAGAKU KENKYUSHO COMPANY, LTD. (JP) 1995-07-18 US claimed
EP-0543307-B1 Nootropic agent SANWA KAGAKU KENKYUSHO CO (JP) 1998-05-06 EP disclosed
US-5434165-A Nootropic agents, compositions of, and method of use thereof SANAWA KAGAKU KENKYUSHO COMPANY, LTD. (JP) 1995-07-18 US disclosed
EP-0543307-A2 Nootropic agent SANWA KAGAKU KENKYUSHO CO., LTD. (JP) 1993-05-26 EP disclosed