Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM4 | Q14833 | 2/20 | 0.43 |
| ▸ | GRM5 | P41594 | 2/20 | 0.42 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
| ▸ | ITK | Q08881 | 1/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 9/20 | 0.42 |
| ▸ | PDE4A | P27815 | 4/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.42 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.42 |
| ▸ | ABL1 | P00519 | 2/20 | 0.42 |
| ▸ | RAF1 | P04049 | 2/20 | 0.41 |
| ▸ | BRAF | P15056 | 2/20 | 0.41 |
| ▸ | HPGDS | O60760 | 1/20 | 0.41 |
| ▸ | GPR6 | P46095 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7357686 | 0.89 | GRM5 (0.42) | GRM4GRM5EGFRITKPDE4D | |
| SCHEMBL7356931 | 0.84 | PDE4D (0.44) | GRM4GRM5PDE4DPDE4APDE4B | |
| SCHEMBL7358483 | 0.82 | PDE4D (0.49) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL7359762 | 0.82 | PDE4D (0.56) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL7362112 | 0.81 | PDE4D (0.50) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL7352793 | 0.80 | BRD4 (0.42) | GRM4GRM5PDE4DPDE4APDE4B | |
| SCHEMBL7363509 | 0.72 | PDE4D (0.49) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL7357750 | 0.72 | LMNA (0.68) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL7359057 | 0.71 | KMT2A (0.65) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL7361091 | 0.71 | PDE4D (0.61) | PDE4DPDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0741707-B1 | SUBSTITUTED AROMATIC COMPOUNDS AS c.AMP PHOSPHODIESTERASE- AND TNF-INHIBITORS | RHONE POULENC RORER LTD (GB) | 1998-04-01 | — | — | EP | claimed |