Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 2/20 | 0.48 |
| ▸ | PDE9A | O76083 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 2/20 | 0.43 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.37 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.37 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.37 |
| ▸ | MET | P08581 | 1/20 | 0.37 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.37 |
| ▸ | FLT1 | P17948 | 1/20 | 0.37 |
| ▸ | LTK | P29376 | 1/20 | 0.37 |
| ▸ | GRK5 | P34947 | 1/20 | 0.37 |
| ▸ | CDK8 | P49336 | 1/20 | 0.37 |
| ▸ | PRKX | P51817 | 1/20 | 0.37 |
| ▸ | NEK2 | P51955 | 1/20 | 0.37 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8554829 | 0.89 | PDE9A (0.61) | PDE5APDE9AMEN1CYP1A2HSP90AA1 | |
| SCHEMBL8557784 | 0.86 | PDE5A (0.47) | PDE5APDE9AALDH1A1MEN1CYP1A2 | |
| SCHEMBL8555426 | 0.80 | CHEK1 (0.49) | KDM4EALDH1A1HSD17B10HPGDSMN1; SMN2 | |
| SCHEMBL7505355 | 0.79 | PDE5A (0.52) | PDE5APDE9AALDH1A1CHEK1DAPK3 | |
| SCHEMBL31328139 | 0.79 | PDE5A (0.52) | PDE5APDE9AALDH1A1CHEK1DAPK3 | |
| SCHEMBL8558570 | 0.79 | KDM4E (0.48) | PDE5APDE9AKDM4EALDH1A1HSD17B10 | |
| SCHEMBL7503779 | 0.79 | CHEK1 (0.55) | PDE5APDE9ACHEK1DAPK3PRKD3 | |
| SCHEMBL7517883 | 0.79 | PDE5A (0.48) | PDE5APDE9AALDH1A1CHEK1DAPK3 | |
| SCHEMBL8557418 | 0.77 | PDE5A (0.49) | PDE5APDE9AALDH1A1HPGDMEN1 | |
| SCHEMBL8556953 | 0.76 | PDE5A (0.48) | PDE5APDE9AALDH1A1CHEK1DAPK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0691970-B1 | IMIDAZOLOQUINOXALINONE DERIVATIVES AS EAA ANTAGONISTS | BASF AG (DE) | 1998-11-11 | — | — | EP | disclosed |