Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | PDE5A | O76074 | 2/20 | 0.46 |
| ▸ | PDE9A | O76083 | 2/20 | 0.46 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.40 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | STAT3 | P40763 | 1/20 | 0.40 |
| ▸ | STAT1 | P42224 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8553493 | 0.89 | PDE9A (0.58) | KDM4EALDH1A1PDE5APDE9AHPGD | |
| SCHEMBL8554950 | 0.84 | PDE5A (0.44) | KDM4EHSD17B10ALDH1A1PDE5APDE9A | |
| SCHEMBL8557199 | 0.83 | PDE5A (0.43) | KDM4EALDH1A1PDE5APDE9AGRIN1 | |
| SCHEMBL9080716 | 0.80 | PDE9A (0.54) | KDM4EHSD17B10LMNAALDH1A1PDE5A | |
| SCHEMBL8554724 | 0.79 | PDE5A (0.48) | KDM4EHSD17B10LMNAALDH1A1PDE5A | |
| SCHEMBL8554829 | 0.78 | PDE9A (0.61) | PDE5APDE9AMAPTKMT2ANPSR1 | |
| SCHEMBL8555764 | 0.78 | PDE5A (0.49) | KDM4EALDH1A1PDE5APDE9AMAPT | |
| SCHEMBL8557792 | 0.77 | PDE5A (0.47) | KDM4EALDH1A1PDE5APDE9AMAPT | |
| SCHEMBL3588054 | 0.77 | PDE9A (0.52) | KDM4EHSD17B10LMNAALDH1A1PDE5A | |
| SCHEMBL7503779 | 0.76 | CHEK1 (0.55) | PDE5APDE9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0691970-B1 | IMIDAZOLOQUINOXALINONE DERIVATIVES AS EAA ANTAGONISTS | BASF AG (DE) | 1998-11-11 | — | — | EP | disclosed |