Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 2/20 | 0.49 |
| ▸ | PDE9A | O76083 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.38 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.35 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8558977 | 0.90 | PDE5A (0.38) | PDE5APDE9AADORA3ALKBH3 | |
| SCHEMBL8553369 | 0.88 | PDE5A (0.45) | PDE5APDE9AADORA3 | |
| SCHEMBL8557015 | 0.87 | PDE9A (0.47) | PDE5APDE9AMEN1KMT2AMAPT | |
| SCHEMBL8557421 | 0.86 | EGLN1 (0.38) | PDE5APDE9AKMT2AADORA3 | |
| SCHEMBL8557792 | 0.85 | PDE5A (0.47) | PDE5APDE9AMEN1KMT2AMAPT | |
| SCHEMBL31328139 | 0.84 | PDE5A (0.52) | PDE5APDE9AMEN1KMT2AMAPT | |
| SCHEMBL8557555 | 0.84 | PDE5A (0.45) | PDE5APDE9AADORA3 | |
| SCHEMBL7505355 | 0.84 | PDE5A (0.52) | PDE5APDE9AMEN1KMT2AMAPT | |
| SCHEMBL8559120 | 0.84 | ADORA3 (0.50) | PDE5APDE9AADORA3 | |
| SCHEMBL8558855 | 0.82 | PDE5A (0.39) | PDE5APDE9AMEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0691970-B1 | IMIDAZOLOQUINOXALINONE DERIVATIVES AS EAA ANTAGONISTS | BASF AG (DE) | 1998-11-11 | — | — | EP | claimed |
| EP-0691970-B1 | IMIDAZOLOQUINOXALINONE DERIVATIVES AS EAA ANTAGONISTS | BASF AG (DE) | 1998-11-11 | — | — | EP | disclosed |