Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP1 | P53582 | 2/20 | 0.54 |
| ▸ | PARP10 | Q53GL7 | 2/20 | 0.43 |
| ▸ | TDP2 | O95551 | 1/20 | 0.43 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.43 |
| ▸ | S100A4 | P26447 | 1/20 | 0.42 |
| ▸ | SRD5A1 | P18405 | 2/20 | 0.39 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.38 |
| ▸ | PTPRC | P08575 | 1/20 | 0.37 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.37 |
| ▸ | BCL2 | P10415 | 1/20 | 0.36 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA4 | P22748 | 1/20 | 0.36 |
| ▸ | CA7 | P43166 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17675410 | 0.85 | METAP1 (0.44) | METAP1PARP10TDP2S100A4HSP90AA1 | |
| SCHEMBL8749446 | 0.81 | PARP10 (0.49) | METAP1PARP10TDP2PARP11S100A4 | |
| SCHEMBL206438 | 0.81 | PARP10 (0.49) | METAP1PARP10TDP2PARP11S100A4 | |
| SCHEMBL1238953 | 0.79 | ACHE (0.46) | METAP1SRD5A1 | |
| SCHEMBL22012874 | 0.79 | METAP1 (0.56) | METAP1PARP10TDP2PARP11S100A4 | |
| SCHEMBL1500072 | 0.79 | METAP1 (0.56) | METAP1PARP10TDP2PARP11S100A4 | |
| SCHEMBL6972986 | 0.79 | METAP1 (0.54) | METAP1PARP10PARP11SRD5A1 | |
| SCHEMBL20951374 | 0.79 | METAP1 (0.53) | METAP1PARP10TDP2PARP11S100A4 | |
| SCHEMBL2370122 | 0.79 | METAP1 (0.53) | METAP1S100A4SRD5A1SRD5A2CES1 | |
| SCHEMBL2065931 | 0.79 | PARP10 (0.46) | METAP1PARP10TDP2PARP11S100A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014089324-A1 | SUBSTITUTED CYCLIC COMPOUNDS AND METHODS OF USE | CALITOR SCIENCES, LLC (US) | 2014-06-12 | — | — | WO | disclosed |
| EP-0662971-B1 | 5H,10H-IMIDAZO[1,2-a]INDENO[1,2-e]PYRAZINE-4-ONE DERIVATIVES, PREPARATION THEREOF AND MEDICAMENTS CONTAINING THEM | RHONE POULENC RORER SA (FR) | 1998-05-13 | — | — | EP | disclosed |
| US-5677306-A | ANTAGONIZING ALPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID RECEPTOR, USEFUL FOR TREATING ALL ISCHEMIAS | RHONE-POULENC RORER S.A. (FR) | 1997-10-14 | — | — | US | disclosed |
| EP-0346107-B1 | Arylfluoroalkenamides and their use as pesticides | ROUSSEL UCLAF (FR) | 1995-09-13 | — | — | EP | disclosed |
| EP-0662971-A1 | DERIVATIVES OF 5H,10H-IMIDAZO 1,2-a]INDENO 1,2-e]PYRAZINE-4-ONE, PREPARATION THEREOF AND MEDICAMENTS CONTAINING THEM | Aventis Pharma S.A. (FR) | 1995-07-19 | — | — | EP | disclosed |
| WO-1994007893-A1 | DERIVATIVES OF 5H,10H-IMIDAZO[1,2-a]INDENO[1,2-e]PYRAZINE-4-ONE, PREPARATION THEREOF AND MEDICAMENTS CONTAINING THEM | RHONE-POULENC RORER S.A. (FR) | 1994-04-14 | — | — | WO | disclosed |
| US-5180737-A | Insecticides, nematocides or anthelmintics | ROUSSEL UCLAF (FR) | 1993-01-19 | — | — | US | disclosed |
| EP-0346107-A2 | Arylfluoroalkenamides and their use as pesticides | ROUSSEL UCLAF (FR) | 1989-12-13 | — | — | EP | disclosed |