Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP1 | P53582 | 2/20 | 0.56 |
| ▸ | ACHE | P22303 | 12/20 | 0.56 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.42 |
| ▸ | TDP2 | O95551 | 1/20 | 0.42 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.42 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.42 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.42 |
| ▸ | PNMT | P11086 | 1/20 | 0.42 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.42 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.42 |
| ▸ | S100A4 | P26447 | 1/20 | 0.41 |
| ▸ | BCL2 | P10415 | 1/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1500072 | 1.00 | METAP1 (0.56) | METAP1ACHEPBRM1TDP2PARP10 | |
| SCHEMBL29980313 | 0.85 | ACHE (0.66) | METAP1ACHEPBRM1PARP10ADRA2A | |
| SCHEMBL6475805 | 0.85 | ACHE (0.66) | METAP1ACHEPBRM1PARP10ADRA2A | |
| SCHEMBL10687118 | 0.82 | PARP10 (0.47) | METAP1ACHEPBRM1TDP2PARP10 | |
| SCHEMBL10687696 | 0.80 | PARP10 (0.45) | METAP1ACHEPBRM1TDP2PARP10 | |
| SCHEMBL2484416 | 0.79 | ACHE (0.73) | METAP1ACHEPARP10PARP11 | |
| SCHEMBL8555030 | 0.79 | METAP1 (0.54) | METAP1PBRM1TDP2PARP10PARP11 | |
| SCHEMBL29404958 | 0.78 | METAP1 (0.56) | METAP1ACHE | |
| SCHEMBL20951374 | 0.78 | METAP1 (0.53) | METAP1PBRM1TDP2PARP10PARP11 | |
| SCHEMBL29594656 | 0.78 | METAP1 (0.53) | METAP1PBRM1TDP2PARP10PARP11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020102576-A1 | COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH NLRP ACTIVITY | NOVARTIS INFLAMMASOME RESEARCH, INC. (US) | 2020-05-22 | — | — | WO | disclosed |