Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRD5A1 | P18405 | 3/20 | 0.46 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | BRD4 | O60885 | 2/20 | 0.42 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.41 |
| ▸ | AADAT | Q8N5Z0 | 1/20 | 0.41 |
| ▸ | HTR2B | P41595 | 3/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30404908 | 0.83 | KMT2A (0.46) | ALOX12ALDH1A1MEN1POLBKMT2A | |
| SCHEMBL11630037 | 0.83 | KMT2A (0.46) | ALOX12ALDH1A1MEN1POLBKMT2A | |
| SCHEMBL10889128 | 0.81 | SRD5A1 (0.46) | SRD5A1ALOX12POLBBRD4MAP2K1 | |
| SCHEMBL30062459 | 0.80 | ALOX12 (0.45) | SRD5A1ALOX12ALDH1A1MEN1POLB | |
| SCHEMBL11272489 | 0.80 | SRD5A1 (0.45) | SRD5A1BRD4MAP2K1HTR1ACYP17A1 | |
| SCHEMBL11270465 | 0.80 | NOTUM (0.49) | SRD5A1POLBMAP2K1AADATHTR2B | |
| SCHEMBL10889135 | 0.80 | SRD5A1 (0.45) | SRD5A1ALDH1A1MEN1KMT2AMAP2K1 | |
| SCHEMBL8551856 | 0.80 | SRD5A1 (0.45) | SRD5A1MEN1KMT2ABRD4MAP2K1 | |
| SCHEMBL3588020 | 0.80 | SRD5A1 (0.45) | SRD5A1ALOX12POLBBRD4MAP2K1 | |
| SCHEMBL3588021 | 0.80 | SRD5A1 (0.45) | SRD5A1ALDH1A1MEN1KMT2ABRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0623614-B1 | 4-Aryl-4-hydroxy-tetrahydropyrans and 3-aryl-3-hydroxy-tetrahydrofurans as 5-lipoxygenase inhibitors | ZENECA LTD (GB) | 1998-02-25 | — | — | EP | disclosed |
| US-5512594-A | ADMINISTERING TO TREAT A MEDICAL CONDITION MEDIATED BY ONE OR MORE LEUKOTRIENES | ZENECA LIMITED (GB) | 1996-04-30 | — | — | US | disclosed |
| US-5478842-A | Antiinflammatory agents, antiallergens, drugs for treatment of diseases mediated by leukotrienes | ZENECA LIMITED (GB) | 1995-12-26 | — | — | US | disclosed |
| WO-1994025453-A1 | 4-ARYL-4-HYDROXY-TETRAHYDROPYRANS AND 3-ARYL-3-HYDROXY-TETRAHYDROFURANS AS 5-LIPOXYGENASE INHIBITORS | ZENECA LIMITED (GB) | 1994-11-10 | — | — | WO | disclosed |
| EP-0623614-A1 | 4-Aryl-4-hydroxy-tetrahydropyrans and 3-aryl-3-hydroxy-tetrahydrofurans as 5-lipoxygenase inhibitors | ZENECA LIMITED (GB) | 1994-11-09 | — | — | EP | disclosed |
| US-4349554-A | Method of using carbostyril derivatives as plant fungicides | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 1982-09-14 | — | — | US | disclosed |