Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 9/20 | 0.52 |
| ▸ | HNF4A | P41235 | 2/20 | 0.52 |
| ▸ | PLK1 | P53350 | 8/20 | 0.51 |
| ▸ | RXRG | P48443 | 6/20 | 0.50 |
| ▸ | RXRB | P28702 | 5/20 | 0.50 |
| ▸ | PLK3 | Q9H4B4 | 3/20 | 0.43 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.41 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.41 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.41 |
| ▸ | RARB | P10826 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8557640 | 1.00 | RXRA (0.52) | RXRAHNF4APLK1RXRGRXRB | |
| SCHEMBL8556422 | 1.00 | RXRA (0.52) | RXRAHNF4APLK1RXRGRXRB | |
| SCHEMBL8555502 | 1.00 | RXRA (0.52) | RXRAHNF4APLK1RXRGRXRB | |
| SCHEMBL8555708 | 0.93 | RXRA (0.52) | RXRAHNF4APLK1RXRGRXRB | |
| SCHEMBL8347443 | 0.88 | PLK1 (0.46) | RXRAHNF4APLK1RXRGRXRB | |
| SCHEMBL8352417 | 0.88 | PLK1 (0.46) | RXRAHNF4APLK1RXRGRXRB | |
| SCHEMBL8345697 | 0.88 | PLK1 (0.46) | RXRAHNF4APLK1RXRGRXRB | |
| SCHEMBL8347040 | 0.88 | PLK1 (0.46) | RXRAHNF4APLK1RXRGRXRB | |
| SCHEMBL8349942 | 0.88 | PLK1 (0.46) | RXRAHNF4APLK1RXRGRXRB | |
| SCHEMBL8347100 | 0.88 | PLK1 (0.46) | RXRAHNF4APLK1RXRGRXRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5709867-A | TREATMENT OF DERMATOLOGICAL, RHEUMATIC, RESPIRATORY, CARDIOVASCULAR, AND OPHTHALMOLOGICAL DISORDERS | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (FR) | 1998-01-20 | — | — | US | claimed |
| US-5709867-A | TREATMENT OF DERMATOLOGICAL, RHEUMATIC, RESPIRATORY, CARDIOVASCULAR, AND OPHTHALMOLOGICAL DISORDERS | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (FR) | 1998-01-20 | — | — | US | disclosed |