Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 6/20 | 0.42 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 7/20 | 0.33 |
| ▸ | CYP11B1 | P15538 | 4/20 | 0.32 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.32 |
| ▸ | TRPV1 | Q8NER1 | 4/20 | 0.32 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.32 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8555580 | 1.00 | ALOX5 (0.42) | ALOX5TRIM24CYP11B2CYP11B1CYP17A1 | |
| SCHEMBL2108616 | 0.89 | ALOX5 (0.46) | ALOX5TRIM24CYP11B2CYP11B1TRPV1 | |
| SCHEMBL2107548 | 0.88 | ALOX5 (0.43) | ALOX5TRIM24CYP11B2CYP11B1CYP17A1 | |
| SCHEMBL2108821 | 0.81 | ATAD2 (0.40) | ALOX5CYP11B2CYP11B1CYP1A2 | |
| SCHEMBL2108067 | 0.80 | CREBBP (0.36) | ALOX5TRIM24 | |
| SCHEMBL9384084 | 0.78 | ALOX5 (0.33) | ALOX5 | |
| SCHEMBL9382242 | 0.78 | ALOX5 (0.33) | ALOX5 | |
| SCHEMBL9275295 | 0.78 | ALOX5 (0.45) | ALOX5TRIM24CYP11B2CYP11B1CYP17A1 | |
| SCHEMBL9271466 | 0.78 | ALOX5 (0.45) | ALOX5TRIM24CYP11B2CYP11B1CYP17A1 | |
| SCHEMBL9274972 | 0.78 | ALOX5 (0.43) | ALOX5TRIM24CYP11B2CYP11B1CYP17A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0623614-B1 | 4-Aryl-4-hydroxy-tetrahydropyrans and 3-aryl-3-hydroxy-tetrahydrofurans as 5-lipoxygenase inhibitors | ZENECA LTD (GB) | 1998-02-25 | — | — | EP | disclosed |
| US-5512594-A | ADMINISTERING TO TREAT A MEDICAL CONDITION MEDIATED BY ONE OR MORE LEUKOTRIENES | ZENECA LIMITED (GB) | 1996-04-30 | — | — | US | disclosed |
| US-5478842-A | Antiinflammatory agents, antiallergens, drugs for treatment of diseases mediated by leukotrienes | ZENECA LIMITED (GB) | 1995-12-26 | — | — | US | disclosed |
| WO-1994025453-A1 | 4-ARYL-4-HYDROXY-TETRAHYDROPYRANS AND 3-ARYL-3-HYDROXY-TETRAHYDROFURANS AS 5-LIPOXYGENASE INHIBITORS | ZENECA LIMITED (GB) | 1994-11-10 | — | — | WO | disclosed |
| EP-0623614-A1 | 4-Aryl-4-hydroxy-tetrahydropyrans and 3-aryl-3-hydroxy-tetrahydrofurans as 5-lipoxygenase inhibitors | ZENECA LIMITED (GB) | 1994-11-09 | — | — | EP | disclosed |