Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRD5A2 | P31213 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.47 |
| ▸ | MAPT | P10636 | 5/20 | 0.47 |
| ▸ | RAB9A | P51151 | 4/20 | 0.47 |
| ▸ | MEN1 | O00255 | 4/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | HPGD | P15428 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15099347 | 0.83 | KDM4E (0.49) | SRD5A2KDM4EALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL699482 | 0.82 | FLT3 (0.60) | KDM4EALDH1A1SMN1; SMN2MAPTRAB9A | |
| SCHEMBL914490 | 0.82 | KDM4E (0.54) | SRD5A2KDM4EALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL700753 | 0.81 | SRD5A2 (0.73) | SRD5A2KDM4EALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL22620709 | 0.80 | KDM4E (0.51) | KDM4EALDH1A1SMN1; SMN2MAPTRAB9A | |
| SCHEMBL913908 | 0.78 | SRD5A2 (0.45) | SRD5A2KDM4EALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL915344 | 0.78 | SRD5A2 (0.45) | SRD5A2KDM4EALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL7005455 | 0.78 | SRD5A2 (0.59) | SRD5A2KDM4EALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL9588071 | 0.78 | ALDH1A1 (0.45) | SRD5A2KDM4EALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL913978 | 0.78 | KDM4E (0.55) | SRD5A2KDM4EALDH1A1SMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0653426-B1 | Indole derivatives, salts thereof and heart affection therapeutic agent comprising the same | KOWA CO (JP) | 1998-07-22 | — | — | EP | disclosed |
| US-5510366-A | INOTROPIC, ANTIARRHYMTHMIA AGENTS, VASODILATORS | KOWA CO., LTD. (JP) | 1996-04-23 | — | — | US | disclosed |
| EP-0653426-A1 | Indole derivatives, salts thereof and heart affection therapeutic agent comprising the same | KOWA COMPANY, LTD. (JP) | 1995-05-17 | — | — | EP | disclosed |