Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | RXRA | P19793 | 5/20 | 0.44 |
| ▸ | RXRB | P28702 | 5/20 | 0.44 |
| ▸ | RXRG | P48443 | 4/20 | 0.44 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | TSHR | P16473 | 3/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | PPARD | Q03181 | 3/20 | 0.40 |
| ▸ | FABP4 | P15090 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8559017 | 0.92 | KMT2A (0.46) | TDP1KMT2ARXRARXRBRXRG | |
| SCHEMBL8561919 | 0.90 | NR4A2 (0.41) | TDP1RXRARXRBRXRGNR4A2 | |
| SCHEMBL8557612 | 0.89 | RXRA (0.43) | TDP1KMT2ARXRARXRBRXRG | |
| SCHEMBL8559035 | 0.88 | GRM5 (0.41) | RXRARXRBRXRGNR4A2PPARD | |
| SCHEMBL8558559 | 0.87 | NR4A2 (0.45) | NR4A2PPARDFABP4RAB9A | |
| SCHEMBL7496715 | 0.85 | RXRA (0.47) | TDP1KMT2ARXRARXRBRXRG | |
| SCHEMBL7506528 | 0.85 | RXRA (0.47) | TDP1KMT2ARXRARXRBRXRG | |
| SCHEMBL8558777 | 0.85 | TDP1 (0.43) | TDP1KMT2ARXRARXRBRXRG | |
| SCHEMBL8555127 | 0.83 | NPC1 (0.41) | RXRARXRBRXRGNR4A2PPARD | |
| SCHEMBL8556137 | 0.83 | NR4A2 (0.47) | KMT2ARXRARXRBRXRGNR4A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5719163-A | ARTHRITIS | G.D. SEARLE & CO. (US) | 1998-02-17 | — | — | US | disclosed |