Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR3 | P29371 | 1/20 | 0.41 |
| ▸ | ESR1 | P03372 | 1/20 | 0.41 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 8/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 6/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 6/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.38 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10311379 | 0.91 | MAPT (0.39) | TACR3ESR1TRPV1MAPTKCNH2 | |
| SCHEMBL10311377 | 0.88 | GRM5 (0.39) | MAPTADORA2AADORA1ADORA2BSCN9A | |
| SCHEMBL7288128 | 0.85 | KCNH2 (0.52) | ESR1MAPTKCNH2ADORA2AADORA1 | |
| SCHEMBL8941191 | 0.85 | KCNH2 (0.52) | ESR1MAPTKCNH2ADORA2AADORA1 | |
| SCHEMBL7278581 | 0.85 | KCNH2 (0.52) | ESR1MAPTKCNH2ADORA2AADORA1 | |
| SCHEMBL8554883 | 0.80 | KCNH2 (0.36) | MAPTKCNH2ADORA2AADORA1CYP3A4 | |
| SCHEMBL16307497 | 0.74 | KDM4E (0.49) | TACR3MAPTCYP3A4KDM4ETP53 | |
| SCHEMBL10674396 | 0.74 | ESR1 (0.51) | ESR1TRPV1ADORA2AADORA1ADORA3 | |
| SCHEMBL7212295 | 0.72 | ADORA2A (0.69) | TACR3MAPTADORA2AADORA1CYP1A2 | |
| SCHEMBL15212407 | 0.72 | ACP1 (0.56) | TACR3MAPTCYP2C19KDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8716265-B2 | 4-quinolinemethanols as anti-malarial agents | JENRIN DISCOVERY, INC. (US) | 2014-05-06 | — | — | US | disclosed |
| US-20120178717-A1 | 4-QUINOLINEMETHANOLS AS ANTI-MALARIAL AGENTS | JENRIN DISCOVERY (US) | 2012-07-12 | — | — | US | disclosed |
| US-20120178717-A1 | 4-QUINOLINEMETHANOLS AS ANTI-MALARIAL AGENTS | JENRIN DISCOVERY (US) | 2012-07-12 | — | — | US | disclosed |
| WO-2012068560-A2 | 4-QUINOLINEMETHANOLS AS ANTI-MALARIAL AGENTS | JENRIN DISCOVERY (US) | 2012-05-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120178717-A1 | 4-QUINOLINEMETHANOLS AS ANTI-MALARIAL AGENTS | CYP51A1, SQLE, NQO2 | TACR3 2943/4885ESR1 4474/4885TRPV1 4217/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.