Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACP1 | P24666 | 7/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.55 |
| ▸ | HPGD | P15428 | 4/20 | 0.55 |
| ▸ | LMNA | P02545 | 4/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.55 |
| ▸ | MAPT | P10636 | 3/20 | 0.55 |
| ▸ | ACACA | Q13085 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.55 |
| ▸ | NPC1 | O15118 | 4/20 | 0.49 |
| ▸ | RAB9A | P51151 | 4/20 | 0.49 |
| ▸ | TP53 | P04637 | 2/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | TACR3 | P29371 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16307497 | 0.87 | KDM4E (0.49) | ACP1ALDH1A1HPGDKDM4EMAPT | |
| SCHEMBL7225702 | 0.81 | MAPT (0.46) | ACP1ALDH1A1LMNAMAPTNPC1 | |
| SCHEMBL7208784 | 0.74 | MAPT (0.49) | KDM4EMAPTTACR3 | |
| SCHEMBL10612092 | 0.73 | MAPT (0.71) | ACP1ALDH1A1HPGDLMNAKDM4E | |
| SCHEMBL20414389 | 0.73 | ALDH1A1 (0.53) | ACP1ALDH1A1HPGDLMNAKDM4E | |
| SCHEMBL25181505 | 0.73 | ACACA (0.97) | ACP1ALDH1A1HPGDLMNAKDM4E | |
| SCHEMBL28967193 | 0.73 | ALDH1A1 (0.59) | ACP1ALDH1A1HPGDLMNAKDM4E | |
| SCHEMBL15212319 | 0.73 | RAB9A (0.63) | ALDH1A1HPGDLMNAKDM4EMAPT | |
| SCHEMBL4196670 | 0.72 | ACACA (0.74) | ACP1ALDH1A1HPGDLMNAKDM4E | |
| SCHEMBL17688779 | 0.72 | ACP1 (1.00) | ACP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140371165-A1 | Identification of NSC23925 Isomers to Reverse Multidrug Resistance in Human Cancers | THE GENERAL HOSPITAL CORPORATION (US) | 2014-12-18 | — | — | US | disclosed |
| US-20140371165-A1 | Identification of NSC23925 Isomers to Reverse Multidrug Resistance in Human Cancers | THE GENERAL HOSPITAL CORPORATION (US) | 2014-12-18 | — | — | US | disclosed |
| WO-2013126664-A1 | IDENTIFICATION OF NSC23925 ISOMERS TO REVERSE MULTIDRUG RESISTANCE IN HUMAN CANCERS | THE GENERAL HOSPITAL CORPORATION (US) | 2013-08-29 | — | — | WO | disclosed |
| WO-2013126664-A1 | IDENTIFICATION OF NSC23925 ISOMERS TO REVERSE MULTIDRUG RESISTANCE IN HUMAN CANCERS | THE GENERAL HOSPITAL CORPORATION (US) | 2013-08-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140371165-A1 | Identification of NSC23925 Isomers to Reverse Multidrug Resistance in Human Cancers | ABCC1, MCL1, ABCB1 | ACP1 4807/4885ALDH1A1 1353/4885HPGD 531/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.