Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | CNR2 | P34972 | 1/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | CCNC | P24863 | 1/20 | 0.45 |
| ▸ | CDK8 | P49336 | 1/20 | 0.45 |
| ▸ | DAGLA | Q9Y4D2 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL713220 | 0.91 | DAGLA (0.48) | PKMRIPK1MAPTMEN1NPC1 | |
| SCHEMBL1730308 | 0.87 | DHFR (0.48) | RIPK1MAPTMEN1NPC1LMNA | |
| SCHEMBL15244018 | 0.81 | MAPT (0.48) | PKMMAPTMEN1NPC1LMNA | |
| SCHEMBL22604313 | 0.81 | MAPT (0.51) | RIPK1MAPTMEN1NPC1LMNA | |
| SCHEMBL25273637 | 0.81 | MAPT (0.48) | MAPTMEN1NPC1LMNARAB9A | |
| Hydrochloric Acid SCHEMBL16931504 | 0.80 | MAPT (0.47) | MAPTMEN1NPC1LMNARAB9A | |
| SCHEMBL18638439 | 0.78 | MAPT (0.50) | RIPK1MAPTMEN1NPC1LMNA | |
| SCHEMBL5861321 | 0.78 | MAPT (0.53) | MAPTMEN1NPC1LMNARAB9A | |
| SCHEMBL2076118 | 0.77 | ALDH1A1 (0.50) | PKMMAPTMEN1NPC1LMNA | |
| SCHEMBL8558135 | 0.77 | ADORA2A (0.48) | PKMMAPTMEN1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0843671-A1 | HETEROCYCLIC COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | GLAXO GROUP LIMITED (GB) | 1998-05-27 | — | — | EP | disclosed |
| WO-1997003069-A1 | HETEROCYCLIC COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | GLAXO GROUP LIMITED (GB) | 1997-01-30 | — | — | WO | disclosed |