Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | ACHE | P22303 | 2/20 | 0.47 |
| ▸ | NAMPT | P43490 | 1/20 | 0.47 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.47 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | BCHE | P06276 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8561936 | 0.90 | ACHE (0.55) | RAB9AMAPTACHEAVPR2AVPR1A | |
| SCHEMBL8562058 | 0.84 | AVPR1A (0.55) | RAB9AMAPTNAMPTAVPR2AVPR1A | |
| SCHEMBL8558605 | 0.82 | AVPR2 (0.57) | AVPR2AVPR1A | |
| SCHEMBL8559251 | 0.81 | AVPR2 (0.68) | AVPR2AVPR1A | |
| SCHEMBL8558166 | 0.81 | AVPR2 (0.57) | AVPR2AVPR1A | |
| SCHEMBL8820852 | 0.80 | AVPR2 (0.49) | TP53MAPTACHEAVPR2AVPR1A | |
| SCHEMBL8563728 | 0.80 | AVPR2 (0.55) | MEN1NPC1RAB9AKMT2ATP53 | |
| SCHEMBL8565071 | 0.80 | AVPR2 (0.48) | AVPR2AVPR1A | |
| SCHEMBL8556570 | 0.80 | AVPR2 (0.56) | MEN1NPC1RAB9AKMT2AAVPR2 | |
| SCHEMBL8562629 | 0.80 | AVPR2 (0.68) | AVPR2AVPR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0640592-B1 | N-acylated tricyclic azaheterorings useful as vasopressin antagonists | AMERICAN CYANAMID CO (US) | 1998-12-30 | — | — | EP | disclosed |
| EP-0640592-A1 | N-acylated tricyclic azaheterorings useful as vasopressin antagonists | AMERICAN CYANAMID COMPANY (US) | 1995-03-01 | — | — | EP | disclosed |