Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | ELANE | P08246 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | THRB | P10828 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | AR | P10275 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 5/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 2/20 | 0.34 |
| ▸ | CASP7 | P55210 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8557622 | 0.80 | ELANE (0.41) | KMT2AMEN1KDM4EELANECYP3A4 | |
| SCHEMBL8558516 | 0.74 | ELANE (0.37) | KMT2AMEN1ELANECYP3A4CYP2C19 | |
| SCHEMBL8556423 | 0.73 | ELANE (0.38) | KMT2AMEN1ELANECYP3A4CYP2C19 | |
| SCHEMBL8555608 | 0.66 | ELANE (0.46) | KMT2AMEN1KDM4EELANECYP3A4 | |
| SCHEMBL8555587 | 0.64 | ELANE (0.54) | KMT2AMEN1KDM4EELANECYP3A4 | |
| SCHEMBL8553103 | 0.63 | ELANE (0.47) | KMT2AMEN1ELANECYP3A4CYP2C19 | |
| SCHEMBL28711416 | 0.63 | ELANE (0.56) | KMT2AMEN1ELANECYP3A4CYP2C19 | |
| SCHEMBL28711419 | 0.62 | ELANE (0.55) | KMT2AMEN1ELANECYP3A4CYP2C19 | |
| SCHEMBL8556687 | 0.61 | ELANE (0.56) | KMT2AMEN1KDM4EELANECYP3A4 | |
| SCHEMBL9867417 | 0.61 | KDM4E (0.43) | KMT2AMEN1KDM4ECYP3A4ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0653426-B1 | Indole derivatives, salts thereof and heart affection therapeutic agent comprising the same | KOWA CO (JP) | 1998-07-22 | — | — | EP | disclosed |
| EP-0653426-A1 | Indole derivatives, salts thereof and heart affection therapeutic agent comprising the same | KOWA COMPANY, LTD. (JP) | 1995-05-17 | — | — | EP | disclosed |