Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 9/20 | 0.49 |
| ▸ | HTR2A | P28223 | 9/20 | 0.49 |
| ▸ | HTR1A | P08908 | 8/20 | 0.49 |
| ▸ | HTR2C | P28335 | 1/20 | 0.49 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.49 |
| ▸ | HRH1 | P35367 | 1/20 | 0.49 |
| ▸ | MAOB | P27338 | 6/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.44 |
| ▸ | DRD1 | P21728 | 1/20 | 0.42 |
| ▸ | DRD4 | P21917 | 1/20 | 0.42 |
| ▸ | DRD5 | P21918 | 1/20 | 0.42 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
| ▸ | HTR1D | P28221 | 1/20 | 0.42 |
| ▸ | HTR1B | P28222 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8556374 | 0.84 | DRD2 (0.63) | DRD2HTR2AHTR1AHTR2CADRA1A | |
| SCHEMBL8557739 | 0.73 | HRH3 (0.48) | HTR2AHTR1AMAOBHRH3 | |
| SCHEMBL8552021 | 0.73 | MEN1 (0.48) | DRD2HTR2AHTR1AHTR2CADRA1A | |
| SCHEMBL8558745 | 0.72 | HRH3 (0.46) | DRD2HTR2AHTR1AHTR2CADRA1A | |
| SCHEMBL9411199 | 0.69 | KDM4E (0.64) | DRD2HTR1ADRD4DRD3 | |
| SCHEMBL9411125 | 0.69 | METAP1 (0.46) | — | |
| SCHEMBL9411187 | 0.67 | HTR2A (0.64) | DRD2HTR2AHTR1ADRD4 | |
| Hydrochloric Acid SCHEMBL9411098 | 0.66 | HTR2A (0.63) | DRD2HTR2ADRD4 | |
| SCHEMBL10274895 | 0.66 | DRD2 (0.78) | DRD2HTR2AHTR1AHTR2CADRA1A | |
| SCHEMBL13663794 | 0.66 | DRD2 (0.73) | DRD2HTR2AHTR1AHTR2CADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0587048-B1 | Heteroarenylpiperazines, a process for their preparation and their use as medicaments | HOECHST MARION ROUSSEL INC (US) | 1998-11-25 | — | — | EP | disclosed |
| EP-0587048-A2 | Heteroarenylpiperazines, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1994-03-16 | — | — | EP | disclosed |
| US-5272148-A | Heteroarenylpiperazines | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1993-12-21 | — | — | US | disclosed |