Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 8/20 | 0.46 |
| ▸ | HTR1A | P08908 | 6/20 | 0.43 |
| ▸ | HTR2A | P28223 | 6/20 | 0.43 |
| ▸ | DRD2 | P14416 | 2/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.43 |
| ▸ | HRH1 | P35367 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8557739 | 0.89 | HRH3 (0.48) | HRH3HTR1AHTR2A | |
| SCHEMBL8552021 | 0.88 | MEN1 (0.48) | HRH3HTR1AHTR2ADRD2HTR2C | |
| SCHEMBL9018128 | 0.82 | ADRA1A (0.52) | HTR1AHTR2ADRD2HTR2CADRA1A | |
| SCHEMBL9597499 | 0.77 | HTR1A (0.52) | HTR1AHTR2ADRD2HTR2CADRA1A | |
| SCHEMBL8552155 | 0.76 | MEN1 (0.48) | HRH3HTR1AHTR2ADRD2HTR2C | |
| SCHEMBL8556374 | 0.76 | DRD2 (0.63) | HTR1AHTR2ADRD2HTR2CADRA1A | |
| SCHEMBL8558649 | 0.74 | HRH3 (0.47) | HRH3HTR1AHTR2ADRD2HTR2C | |
| SCHEMBL9596902 | 0.72 | ADRA1A (0.51) | HTR1AHTR2ADRD2HTR2CADRA1A | |
| SCHEMBL8556493 | 0.72 | DRD2 (0.49) | HRH3HTR1AHTR2ADRD2HTR2C | |
| SCHEMBL8556614 | 0.72 | HRH3 (0.66) | HRH3HTR1AHTR2ADRD2HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0587048-B1 | Heteroarenylpiperazines, a process for their preparation and their use as medicaments | HOECHST MARION ROUSSEL INC (US) | 1998-11-25 | — | — | EP | disclosed |
| EP-0587048-A2 | Heteroarenylpiperazines, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1994-03-16 | — | — | EP | disclosed |
| US-5272148-A | Heteroarenylpiperazines | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1993-12-21 | — | — | US | disclosed |