SCHEMBL8556523

SCHEMBL8556523

NC(=O)c1nccn1C1Cc2cc(Cl)ccc2C1=O

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
METAP1 P53582 1/20 0.38
HTR2A P28223 5/20 0.37
HTR2C P28335 5/20 0.37
HTR1A P08908 4/20 0.37
HTR7 P34969 4/20 0.37
DRD4 P21917 3/20 0.37
DRD3 P35462 3/20 0.36
DRD2 P14416 2/20 0.36
SLC6A4 P31645 1/20 0.36
CYP11B2 P19099 2/20 0.35
SIGMAR1 Q99720 2/20 0.35
AADAT Q8N5Z0 1/20 0.34
FNTA P49354 3/20 0.34
FNTB P49356 3/20 0.34
SLC6A15 Q9H2J7 3/20 0.34
CYP11B1 P15538 1/20 0.34
HRH1 P35367 4/20 0.33
HTR2B P41595 2/20 0.33
GRM1 Q13255 1/20 0.33
GRM4 Q14833 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7844165 0.91 HTR2A (0.37) HTR2AHTR2CHTR1AHTR7DRD4
SCHEMBL8557548 0.89 METAP1 (0.38) METAP1HTR2AHTR2CHTR1AHTR7
SCHEMBL8559601 0.86 METAP1 (0.38) METAP1HTR2AHTR2CAADATHTR2B
SCHEMBL8315983 0.86 DRD3 (0.37) HTR2AHTR2CHTR1AHTR7DRD4
SCHEMBL8552754 0.86 METAP1 (0.38) METAP1PTAFR
SCHEMBL8555113 0.83 KDM4E (0.40) METAP1
SCHEMBL8880066 0.83 HRH1 (0.43) METAP1HTR2ASLC6A15HRH1HTR2B
SCHEMBL8881314 0.81 PDE3B (0.46) HTR2AHTR2CHTR2B
SCHEMBL7848070 0.80 HTR2A (0.38) HTR2AHTR2CHTR1AHTR7DRD4
SCHEMBL8683487 0.78 MAOA (0.38)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0662971-B1 5H,10H-IMIDAZO[1,2-a]INDENO[1,2-e]PYRAZINE-4-ONE DERIVATIVES, PREPARATION THEREOF AND MEDICAMENTS CONTAINING THEM RHONE POULENC RORER SA (FR) 1998-05-13 EP disclosed
US-5677306-A ANTAGONIZING ALPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID RECEPTOR, USEFUL FOR TREATING ALL ISCHEMIAS RHONE-POULENC RORER S.A. (FR) 1997-10-14 US disclosed
EP-0662971-A1 DERIVATIVES OF 5H,10H-IMIDAZO 1,2-a]INDENO 1,2-e]PYRAZINE-4-ONE, PREPARATION THEREOF AND MEDICAMENTS CONTAINING THEM Aventis Pharma S.A. (FR) 1995-07-19 EP disclosed
WO-1994007893-A1 DERIVATIVES OF 5H,10H-IMIDAZO[1,2-a]INDENO[1,2-e]PYRAZINE-4-ONE, PREPARATION THEREOF AND MEDICAMENTS CONTAINING THEM RHONE-POULENC RORER S.A. (FR) 1994-04-14 WO disclosed