SCHEMBL8559601

SCHEMBL8559601

Cc1ccc2c(c1)CC(n1ccnc1C(N)=O)C2=O

nearest known ligand 0.38

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
METAP1 P53582 2/20 0.38
AADAT Q8N5Z0 2/20 0.34
PTAFR P25105 1/20 0.33
HTR2A P28223 1/20 0.33
HTR2C P28335 1/20 0.33
HTR2B P41595 1/20 0.33
ACHE P22303 3/20 0.33
GRM1 Q13255 1/20 0.32
GRM4 Q14833 1/20 0.32
PARP10 Q53GL7 1/20 0.32
PARP11 Q9NR21 1/20 0.32
ALDH1A1 P00352 1/20 0.32
CDC7 O00311 1/20 0.31
CCNE1 P24864 1/20 0.31
CDK2 P24941 1/20 0.31
DBF4 Q9UBU7 1/20 0.31
CDK8 P49336 1/20 0.30
CDK19 Q9BWU1 1/20 0.30
PDE4A P27815 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8558748 0.89 METAP1 (0.39) METAP1AADATPTAFRHTR2AHTR2C
SCHEMBL8552754 0.86 METAP1 (0.38) METAP1PTAFRPARP10PARP11
SCHEMBL8556523 0.86 METAP1 (0.38) METAP1AADATPTAFRHTR2AHTR2C
SCHEMBL8315983 0.86 DRD3 (0.37) PTAFRHTR2AHTR2CHTR2BACHE
SCHEMBL8880656 0.84 METAP1 (0.38) METAP1ALDH1A1
SCHEMBL8555113 0.83 KDM4E (0.40) METAP1ACHEALDH1A1
SCHEMBL8881314 0.81 PDE3B (0.46) HTR2AHTR2CHTR2B
SCHEMBL7844165 0.79 HTR2A (0.37) AADATPTAFRHTR2AHTR2CHTR2B
SCHEMBL8683487 0.78 MAOA (0.38) ALDH1A1
SCHEMBL8555247 0.77 ACHE (0.44) AADATHTR2AHTR2CHTR2BACHE

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0662971-B1 5H,10H-IMIDAZO[1,2-a]INDENO[1,2-e]PYRAZINE-4-ONE DERIVATIVES, PREPARATION THEREOF AND MEDICAMENTS CONTAINING THEM RHONE POULENC RORER SA (FR) 1998-05-13 EP disclosed
US-5677306-A ANTAGONIZING ALPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID RECEPTOR, USEFUL FOR TREATING ALL ISCHEMIAS RHONE-POULENC RORER S.A. (FR) 1997-10-14 US disclosed
EP-0662971-A1 DERIVATIVES OF 5H,10H-IMIDAZO 1,2-a]INDENO 1,2-e]PYRAZINE-4-ONE, PREPARATION THEREOF AND MEDICAMENTS CONTAINING THEM Aventis Pharma S.A. (FR) 1995-07-19 EP disclosed
WO-1994007893-A1 DERIVATIVES OF 5H,10H-IMIDAZO[1,2-a]INDENO[1,2-e]PYRAZINE-4-ONE, PREPARATION THEREOF AND MEDICAMENTS CONTAINING THEM RHONE-POULENC RORER S.A. (FR) 1994-04-14 WO disclosed