Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 3/20 | 0.58 |
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.58 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.58 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.58 |
| ▸ | MAOA | P21397 | 4/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.48 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.43 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.43 |
| ▸ | GRM5 | P41594 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 3/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.42 |
| ▸ | CASP1 | P29466 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9303814 | 0.88 | ALDH1A1 (0.52) | HTR2ALOXL2SMN1; SMN2CYP2A6TAAR1 | |
| SCHEMBL3918835 | 0.86 | HTR2A (0.52) | HTR2ALOXL2SMN1; SMN2CYP2A6TAAR1 | |
| SCHEMBL94697 | 0.82 | ALDH1A1 (0.48) | HTR2ALOXL2SMN1; SMN2CYP2A6TAAR1 | |
| SCHEMBL14085350 | 0.82 | HTR2A (0.46) | HTR2ALOXL2SMN1; SMN2CYP2A6TAAR1 | |
| SCHEMBL8552074 | 0.79 | TDP1 (0.54) | SMN1; SMN2MAOBALDH1A1CASP1HSD17B10 | |
| SCHEMBL5966248 | 0.79 | GRM5 (0.50) | HTR2ASMN1; SMN2MAOAGRM5MAOB | |
| SCHEMBL6014476 | 0.79 | SMN1; SMN2 (0.48) | HTR2ALOXL2SMN1; SMN2CYP2A6TAAR1 | |
| SCHEMBL5700795 | 0.79 | FFAR1 (0.49) | HTR2ALOXL2SMN1; SMN2CYP2A6TAAR1 | |
| SCHEMBL6738643 | 0.78 | ALDH1A1 (0.48) | HTR2ALOXL2SMN1; SMN2CYP2A6TAAR1 | |
| Phenethylamine SCHEMBL29822489 | 0.78 | HTR2A (0.94) | HTR2ALOXL2SMN1; SMN2CYP2A6TAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0840725-A1 | AZETIDINONE DERIVATIVES FOR THE TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 1998-05-13 | — | — | EP | disclosed |
| WO-1997002242-A1 | AZETIDINONE DERIVATIVES FOR THE TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 1997-01-23 | — | — | WO | disclosed |